N,N′,N″,N‴-Tetraisopropylpyrophosphoramide 1 is a pyrophosphoramide with documented butyrylcholinesterase inhibition, property shared the more widely studied octamethylphosphoramide (Schradan). Unlike Schradan, solid at room temperature making it one of few known solids. The crystal structure was determined by single-crystal X-ray diffraction and compared that other previously described pyropho...

A highly efficient procedure for the preparation of N,N'-alkylidenebisamides in the presence of BF3.SiO2 as a catalyst is described. N,N'-alkylidenebisamides have been prepared via one-pot three-component condensation reaction of various aldehydes and amides. All of the reactions proceeded in high yields and in moderately short reaction times.