BACKGROUND RHOGTPases play a significant role in modulating myometrial contractility in uterine smooth muscle. They are regulated by at least three families of proteins, RHO guanine nucleotide exchange factors (RHOGEFs), RHOGTPase-activating proteins (RHOGAPs) and RHO guanine nucleotide inhibitors (RHOGDIs). RHOGEFs activate RHOGTPases from the inactive GDP-bound to the active GTP-bound form. R...

The association between etio-pathogenesis of morbidly adherent placenta (MAP) or placenta cretas and adenomyosis has never been described in medical literature. Contrary to the believe that MAP is due to direct invasion of trophoblastic tissues into the adjacent normal myometrium due to prior uterine surgeries, this article describes how pre-existence of adenomyosis acts as a precursor for the ...

OBJECTIVE To evaluate the effectiveness of a laparoscopic niche resection on niche-related symptoms and/or fertility-related problems, ultrasound findings and quality of life. DESIGN Prospective cohort study. SETTING University hospital. POPULATION Women with a large niche (residual myometrium <3 mm) and complaints of either postmenstrual spotting, dysmenorrhoea, intrauterine fluid accumu...

Human myometrium develops phasic contractions during labor. Phosphorylation of caldesmon (h-CaD) and extracellular signal-regulated kinase 1/2 (ERK 1/2) has been implicated in development of these contractions, however the phospho-regulation of these proteins is yet to be examined during periods of both contraction and relaxation. We hypothesized that protein phosphorylation events are implicat...

OBJECTIVES DNA fragmentation factors 40 and 45 (DFF40 and DFF45) are responsible for final DNA-laddering during apoptosis, whereas Bcl-2 (B-cell lymphoma 2) is an apoptosis inhibitor. Our aim was to investigate the expression of DFF40, DFF45, and Bcl-2 in uterine leiomyosarcomas (uLMS), leiomyomas (uLM), and the normal myometrium. Furthermore, the correlation between DFF40, DFF45, and Bcl-2 exp...

The objective: a study of the electronic microscopic features decidual membrane in pregnant women with placenta previa. Materials and methods. 122 atypical location were examined delivered within 36 weeks+6 days 38-39 weeks gestation Kyiv Perinatal Center during 2014–2020. Electronic microscopy was performed 10 Decidual biopsy directly from site previa uterine body outside Results. By endometri...

an invasive mole is a rare form of gestational trophoblastic disease in which the molar tissue invades into the deep myometrium, cervical stroma, blood vessels or extrauterine sites. this report is of an invasive mole of spleen that has originated from an ectopic pregnancy, which was primarily though to be a choriocarcinoma.

Calina papaya leaf is an Indonesian plant type that has the potential to be used as a medicinal plant. Phytochemical compounds found in leaves act antifertility agents. The research aimed study effect of ethanol extract on estrus cycle and uterine morphology wistar rats. experiment lasted 30 days involved 25 female treatment consisted 5 groups, namely K (distilled water), K+ (contraceptive pill...