T he paper by Bonow et al' in this issue of Circulation reports important empirical observations on measuring myocardial viability in humans with the potassium analogue thallium-201. After obtaining standard 20'1f exercise and redistribution images, a second dose of 201TI was injected and a third (reinjection) image was obtained beginning 10-15 minutes later. The reinjection images identified v...

T he paper by Bonow et al' in this issue of Circulation reports important empirical observations on measuring myocardial viability in humans with the potassium analogue thallium-201. After obtaining standard 20'1f exercise and redistribution images, a second dose of 201TI was injected and a third (reinjection) image was obtained beginning 10-15 minutes later. The reinjection images identified v...

BACKGROUND It has been hypothesized that a long-term response to cardiac resynchronization therapy (CRT) could correlate with myocardial viability in patients with left ventricular (LV) dysfunction. Contractile reserve and viability in the region of the pacing lead have not been investigated in regard to acute response after CRT. METHODS Fifty-one consecutive patients with advanced heart fail...

Accurate assessment of myocardial viability is a central goal in clinical diagnosis of ischemic heart disease, as well as in basic research into the underlying mechanisms of cardiac pathology. Clinical assessment of myocardial viability would have a significant impact on the management of patients with ischemic heart disease, by avoiding unnecessary revascularization procedures, as well as asse...

The protective effects of ilexsaponin A on ischemia-reperfusion-induced myocardial injury were investigated. Myocardial ischemia/reperfusion model was established in male Sprague-Dawley rats. Myocardial injury was evaluated by TTC staining and myocardial marker enzyme leakage. The in vitro protective potential of Ilexsaponin A was assessed on hypoxia/reoxygenation cellular model in neonatal rat...

OBJECTIVES Early evaluation of myocardial viability in acute myocardial infarction is useful to guide therapy. Therefore, we assessed 64-slice computed tomography (CT) immediately after coronary angiography in this setting. BACKGROUND Recent preliminary studies have shown the promising usefulness of late hyperenhancement multislice computed tomography (MSCT) for non-viability assessment. ME...

S tress echocardiography (pharmaceutical or exercise) represents an important diagnostic method for the evaluation of coronary artery disease (myocardial ischemia and/or viability). The commonest protocol applied in stress echocardiography is carried out with intravenous administration of dobutamineatropine. Although some adverse reactions may appear during this procedure, many studies have pro...

BACKGROUND Low-dose dobutamine stress echocardiography (DSE) assesses myocardial viability at the early stage of acute myocardial infarction (AMI), but its assessment is subjective and variable. Automated function image (AFI) determines global longitudinal peak strain (GLPS) based on tissue tracking technique. The ability of GLPS obtained by AFI during dobutamine stress to assess myocardial via...

myocardial perfusion spect imaging with tc99m-sestamibi is the most accurate non-invasive means of detecting coronary artery disease and assessing the severity of perfusion abnormalities in the patients with coronary stenosis. though simple and straight forward the results produced by the technique is very much affected by the details being used. one of the main problems with the test, which ha...

BACKGROUND Myocardial viability in area at risk of acute myocardial infarction (AMI) after reperfusion therapy may be underestimated by the 24-hour images due to reverse redistribution (r-RD). METHODS Subjects were 37 AMI patients in whom Tc-99m pyrophosphate (PYP)/Tl-201 dual-isotope SPECT was positive. The 24-hour delayed scan was performed with only a Tl window. One month later, follow up ...