Ruptured abdominal aortic aneurysm (RAAA) repair, a combination of hemorrhagic shock and lower-torso ischemia, is associated with a 50-70% mortality. Myocardial dysfunction may contribute to the high rate of mortality after aneurysm repair. We attempted to determine whether RAAA repair results in cardiac dysfunction mediated by tumor necrosis factor-alpha (TNF-alpha). We modeled aortic rupture ...

BACKGROUND We have shown that BNIP3 expression is significantly increased in heart failure (HF). In this study, we tested the effects of BNIP3 manipulation in HF. METHODS AND RESULTS In a rat model of pressure overload HF, BNIP3 knockdown significantly decreased left ventricular (LV) volumes with significant improvement in LV diastolic and systolic function. There were significant decreases i...

conclusions our results demonstrated the ability of pw-tdi and s/sr modalities in detection of the early subclinical abnormalities in asymptomatic patients with significant chronic ar. results ar group had significantly increased lv end systolic and end diastolic volumes, interventricular septum and posterior wall thickness compared to controls. in ar, sm and em of septal wall, sm of lateral wa...

BACKGROUND Cardiomyopathy and distal symmetrical polyneuropathy (DSPN), including sensory and autonomic dysfunction, often co-occur in diabetic mellitus (DM) patients. However, the temporal relationship and progression between these two complications has not been investigated. Using a streptozotocin DM animal model that develops insensate neuropathy, our aim was to examine in parallel the devel...

Heinzel FR, Hohendanner F, Jin G, Sedej S, Edelmann F. Myocardial hypertrophy and its role in heart failure with preserved ejection fraction. J Appl Physiol 119: 1233–1242, 2015. First published July 16, 2015; doi:10.1152/japplphysiol.00374.2015.—Left ventricular hypertrophy (LVH) is the most common myocardial structural abnormality associated with heart failure with preserved ejection fraction...

BACKGROUND Acute neurogenic pulmonary edema, a common and underdiagnosed clinical entity, can occur after virtually any form of injury of the central nervous system and is a potential early contributor to pulmonary dysfunction in patients with head injuries. OBJECTIVE To explore myocardial function in patients with evident neurogenic pulmonary edema after traumatic head injury. METHODS Duri...

background: despite the emerging evidence on beneficial effects of probiotics on the cardiovascular system, their impact on the management of ischemic heart diseases and its possible mechanism have not been elucidated. methods: four viable probiotics bacterial strains, including bifidobacterium breve, lactobacillus casei, lactobacillus bulgaricus and lactobacillus acidophilus, at the concentrat...

Previous studies have confirmed that traumatic brain injury (TBI) can induce general adaptation syndrome (GAS), which subsequently results in myocardial dysfunction and damage in some patients with acute TBI; this condition is also termed as cerebral-cardiac syndrome. However, most clinicians ignore the detection and treatment of myocardial dysfunction, and instead concentrate only on the serio...

Since its original description 50 years ago, myocardial ischemia has been a recognized but underappreciated aspect of the pathophysiology of hypertrophic cardiomyopathy (HCM). Nevertheless, the assessment of myocardial ischemia is still not part of routine clinical diagnostic or management strategies. Morphologic abnormalities of the intramural coronary arterioles represent the primary morpholo...

Shahani, Rohan, John G. Marshall, Barry B. Rubin, Ren-Ke Li, Paul M. Walker, and Thomas F. Lindsay. Role of TNF-a in myocardial dysfunction after hemorrhagic shock and lower-torso ischemia. Am. J. Physiol. Heart Circ. Physiol. 278: H942–H950, 2000.—Ruptured abdominal aortic aneurysm (RAAA) repair, a combination of hemorrhagic shock and lower-torso ischemia, is associated with a 50–70% mortality...