The objective of this study was to investigate the ultrastructural characteristics of hybrid acute leukemia (HAL). Fifteen cases of HAL were studied by transmission electron microscopy (TEM), focusing on organelles and myeloperoxidase (MPO) reaction of leukemic cells. By TEM, 5 out 15 cases of HAL were consistent with immunophenotyping (3 cases of biphenotypic type, and 2 cases of biclonal type...

The first detailed report of a specific interaction of CP (caeruloplasmin) with another protein described its complex with LF (lactoferrin) in 2000. Since then, several protein-protein interactions involving CP have been reported, mostly concerning iron-containing proteins. The CP-LF complex was studied thoroughly, and evidence of reciprocal effects of CP and LF was obtained. Another specific i...

A scheme was constructed for synthesizing a magnetic resonance imaging (MRI) contrast agent with both myeloperoxidase (MPO) sensing and superoxide dismutase (SOD) therapeutic ability. This contrast agent was designed by modifying a previously published paramagnetic SOD mimetic with therapeutic ability to contain a substrate group for MPO. This allows the contrast agent to accumulate in sites of...

Heart failure in children is a global major health problem. Inflammation an important role pathophysiology of heart failure. Myeloperoxidase (MPO) included to the inflammation cascade. The objective was analyze correlation between MPO with severity children. Observational analytic cross sectional study conducted on aged 1 month-18 years acyanotic CHD or without at Dr. Soetomo General Hospital S...

Myeloperoxidase (MPO) is a critical component in the oxygen-dependent microbicidal activity of neutrophils. Hereditary deficiency of MPO occurs commonly, but its genetic basis has not been determined. Previously we have reported the presence of an 89-kilodalton protein, likely pro-MPO, in normal and MPO-deficient neutrophils and hypothesized that the absence of peroxidase activity in neutrophil...

Background: Neutrophil extracellular traps (NETs) are chromatin complexes of cell-free DNA and histones, with attached neutrophil granular proteins which trap kill infectious microbes. NETs essential in host defense, also linked to inflammation autoimmunity, including systemic lupus erythematosus (SLE) recently emerged as contributor arterial venous thrombosis. Common carotid intema media thick...

Myeloperoxidase (MPO) is released by activated immune cells and forms the oxidants hypochlorous acid (HOCl) hypothiocyanous (HOSCN) from competing substrates chloride thiocyanate. MPO overproduction of HOCl are strongly linked with vascular cell dysfunction inflammation in atherosclerosis. highly reactive causes marked death, whereas data HOSCN conflicting, dependent on nature type. In this stu...

The nitroxide tempol (4-hydroxy-2,2,6,6-tetramethyl piperidine-1-oxyl) reduces tissue injury in animal models of inflammation by mechanisms that are not completely understood. MPO (myeloperoxidase), which plays a fundamental role in oxidant production by neutrophils, is an important target for anti-inflammatory action. By amplifying the oxidative potential of H2O2, MPO produces hypochlorous aci...