Ex vivo models for the noninvasive study of myelin-related diseases represent an essential tool to understand mechanisms and develop therapies against them. Herein, we assessed potential multimodal imaging traceable myelin-targeting liposomes quantify myelin in organotypic cultures. Methods: MRI testing was used image mouse cerebellar tissue sections Demyelination induced by lysolecithin treatm...

As ingenious as nature's invention of myelin sheaths within the mammalian nervous system is, as fatal can be damage to this specialized lipid structure. Long-term loss of electrical insulation and of further supportive functions myelin provides to axons, as seen in demyelinating diseases such as multiple sclerosis (MS), leads to neurodegeneration and results in progressive disabilities. Multipl...