The aim of the present study was to evaluate angiogenesis by determining the micro vascular density (MVD) and the expression of vascular endothelial growth factor (VEGF-A) in advanced non-small cell lung cancer (NSCLC) tumor samples, and to analyze their associations with clinical parameters and survival. Tumor tissue specimens of fifty patients (41 males and 9 females), who underwent radical s...

Tinnitus is the hearing of sound mostly within one’s ears or sometimes within one’s head, without external acoustic stimulus. Tinnitus is a common symptom, which can often be easily cured through medication, noise masking, or psychotherapy, but 10% of cases are considered intractable, causing patients to suffer from insomnia, interference with concentration, and hearing disturbance. If left unc...

TSP-1 is a large extracellular matrix glycoprotein implicated in angiogenesis. Its specific role is not clear, as both stimulatory and inhibitory effects have been demonstrated in animal models ( I , 2). Angiogenesis cannot be measured directly in human tumours, however, the density of the microvasculature in tissue sections has been commonly used as an index of this process. Although angiogene...

The quantification of angiogenic and linfangiogenic factors has been explored in an attempt to predict the prognosis of various malignancies. In gastric cancer (GC), a promising parameter is the microvessel density (MVD). Objective: The aim of our study is to evaluate the different methods used for its quantification. Methods: 52 cases of GC were labeled by immunohistochemistry for CD34, CD105 ...

Dear Editor, Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world that is frequently diagnosed by obtaining core needle biopsies. However, distinguishing a well-differentiated HCC from benign hepatic lesions, such as fatty liver, hepatitis, cirrhosis, and adenomas, particularly in these small specimens, can be quite challenging. In this study, we used the microvess...

Objective: To investigate the expression of vasohibin-1 (VASH-1) and microvessel density (MVD) marked with CD34 in clear cell renal cell carcinoma (ccRCC) and analyze their correlations with prognosis. Methods: From January 2006 to December 2008, the clinical and pathologic data of 79 patients with ccRCC were retrospectively analyzed. Expressions of VASH1 and CD34 in their tissue samples were d...

Mentalis muscle responses to electrical stimulation of the zygomatic branch of the facial nerve are considered abnormal muscle responses (AMRs) and can be used to monitor the success of decompression in microvascular decompression (MVD) surgery. The aim of this study was to compare the long-term outcome of MVD surgery in which the AMR disappeared to the outcome of surgery in which the AMR persi...

PURPOSE AND EXPERIMENTAL DESIGN The purpose is to define intratumoral microvessel density (MVD) and potential biological markers that correlate with inflammatory breast cancer (IBC), we examined MVD, estrogen receptor a (ER) status, MIB-1 proliferation index, p53, and c-erbB-2 by immunohistochemistry in archival specimens from 67 women diagnosed with breast cancer with or without the inflammato...

OBJECTIVE The purpose of this large prospective study is to assess the association between the disappearance of the lateral spread response (LSR) before and after microvascular decompression (MVD) and clinical long term results over two years following hemifacial spasm (HFS) treatment. METHODS Continuous intra-operative monitoring during MVD was performed in 244 consecutive patients with HFS....

Objective: The purpose of this study was to evaluate the correlation between CT perfusion parameters and the hypoxia-inducible factor-1 alpha (HIF-1α), vascular endothelial growth factor (VEGF), matrix metalloproteinase-2 (MMP-2) and microvessel density (MVD) marked by CD34 molecular of rabbit VX2 liver tumors and to investigate the value of CT perfusion imaging in evaluating tumor angiogenesis...