introduction: in this study, we investigated the role of n-methyl-d-aspartate (nmda) receptors in the ventral hippocampus (vh) and their possible interactions with gabaa system on anxiety-like behaviors. methods: we used an elevated-plus maze test (epm) to assess anxiety-like behaviors and locomotor activity in male wistar rats. results: the results showed that intra-vh infusions of different d...

UNLABELLED Evidence suggests that gamma-aminobutyric acid (GABA) signalling in the basolateral amygdala (BLA) is involved in pain, fear, and fear-conditioned analgesia (FCA). In this study, we investigated the effects of intra-BLA administration of the GABA(A) receptor agonist muscimol on the expression of conditioned-fear, formalin-evoked nociception, and fear-conditioned analgesia in rats, an...

t-Butylbicyclophosphorothionate (TBPS) is a bicyclophosphate derivative with potent picrotoxin-like convulsant activity that binds with high affinity and specificity to a Cl- channel-modulatory site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex. Using intact cerebellar granule cells maintained in primary culture, we have studied the modifications induced by GABA and diaz...

We studied the effects of microinjected drugs and brainstem lesions on motor and limbic seizures in the kindling model of epilepsy. The duration of motor seizures was determined by timing the colonic and tonic movements of the extremities. The duration of limbic seizures was determined by measuring afterdischarge recorded on the electroencephalogram. Bilateral microinjection of a gamma-aminobut...

29 It has been suggested that the dorsal premotor cortex (PMd) may contribute to 30 conditional motor behavior. Thus, when a selection is instructed by arbitrary conditional 31 cues, it is possible that the unilateral PMd affects behavior, regardless of which arm, 32 contraor ipsilateral, is to be used. We examined this possibility by recording neuronal 33 activity and injecting muscimol into t...

t-Butylbicyclophosphorothionate (TBPS), a derivative of potent GABA antagonistic cage convulsants, has recently been introduced (Squires, R. F., J. E. Casida, M. Richardson, and E. Saederup (1983) Mol. Pharmacol. 13: 326-336) as ligand for a GABA-A receptor-linked drug receptor. Using conventionally prepared washed membrane fractions from rat cerebral cortex, we have confirmed that in the prese...

After extinction of fear to a Pavlovian conditional stimulus (CS), contextual stimuli come to regulate the expression of fear to that CS. There is growing evidence that the context dependence of memory retrieval after extinction involves the hippocampus. In the present experiment, we examine whether hippocampal involvement in memory retrieval after extinction is related to the history of CS pre...

A previous study identified neuronal activity in area 5 of the monkey posterior parietal cortex that reflects the numerosity of a series of self-performed actions. It is not known, however, whether area 5 is crucially involved in the selection of an action based on numerical information or, instead, merely reflects numerosity-related signals that originate in other brain regions. We transiently...