A murine model of spontaneous metastasis of mammary adenocarcinomas in mice was developed by serial transplantation of spontaneous BALB/cfC3H/Crgl tumours into the mammary gland. Through 8 transplant generations, 5 lines demonstrated maintenance of metastatic phenotype and consistent gross and histological morphology and growth properties. Tumour lines M12, M35, and M51 metastasized from the ma...

The administration of pituitary growth hor mone (STH) to C3H mice bearing transplanted mammary adenocarcinoma has been shown to cause an increase in the tumor and animal weights when the mice were sacrificed at the end of a 27day injection period (5). It was also observed that the animals receiving STH appeared generally healthier than did their respective controls at the time they were sacrifi...

BALB/c mice are susceptible to radiation-induced mammary tumors as well as lymphomas. We investigated the effects of the p53 deficient allele and of X-irradiation on the tumor spectrum in the BALB/c background. Substantially all p53 -/-animals died of thymic lymphomas before 36 weeks of age, while none of the p53 +/+ animals died during that period. At this age, mortalities of p53 +/- females a...

Intrauterine and early life exposure to folic acid has significantly increased in North America owing to folic acid fortification, widespread supplemental use, and periconceptional supplementation. We investigated the effects of maternal and postweaning folic acid supplementation on mammary tumor risk in the offspring. Female rats were placed on a control or folic acid-supplemented diet prior t...

The role of the endoplasmic reticulum stress-regulated kinase, PERK, in mammary gland function was assessed through generation of a targeted deletion in mammary epithelium. Characterization revealed that PERK is required for functional maturation of milk-secreting mammary epithelial cells. PERK-dependent signaling contributes to lipogenic differentiation in mammary epithelium, and perk deletion...

Sarcopoterium spinosum (L.) is a medicinal plant traditionally used for the treatment of various diseases including cancer in Near- and Middle East. The fractions constituents ethanol extract S. were screened vitro cytotoxic activities on Jurkat (acute T-lymphoblastic leukemia), HeLa (cervical adenocarcinoma), MCF-7 (mammary gland Caco-2 (human colorectal MDA-MB-231 adenocarcinoma) cell lines u...

Eight new feline mammary adenocarcinoma cell lines derived from either primary or metastatic lesions were established. The morphology of all the cell lines was epithelioid and round to spindle in shape, with cell growth occurring in a monolayer fashion. On immunohistochemistry, these cells reacted with anti-keratin and anti-vimentin antisera. The doubling time of these cells was between 19 and ...

Mammary Paget disease is the intraepidermal adenocarcinoma of the nipple area which is characterized usually by a well-demarcated eczematous plaque. Reflectance confocal microscopy (RCM), is an in vivo noninvasive diagnostic tool with a high-resolution imaging of the skin, almost comparable to conventional histology. RCM findings of Paget disease are limited in the literature. Most of the repor...

Nuclei from a mammary adenocarcinoma and liver indigenous to the same mouse, isolated by two different methods, were shown to contain adenosine triphosphatase (ATPase) activity. The distribution of ATPase activity in subcellular portions of the transplanted mammary tumor was ascertained and found to be highest in the mitochondrial and nuclear moieties. Comparison was made between the ATPase act...