multiple sclerosis (ms) is a demyelinating disease of the central nervous system,with unknown etiology in which both genetic and environmental factors are thought to be involved. the hla system provides a set of genetic markers which lend themselves to systematic study. the disease also has variable clinical manifestations, ranging from a relapsing-remitting course to a chronic progressive dise...

objective: multiple sclerosis (ms) is a disease with a detrimental effect on functional status. the present study investigated the effect of a sexual therapy program on the quality of life (qol) of women with multiple sclerosis. method: women with multiple sclerosis and sexual dysfunction (n = 30) were selected, and were randomly assigned into the treatment (n = 15), or the control groups (n = ...

Celiac disease (CD) has traditionally been thought of as a primarily intestinal disorder, and is now considered the most important autoimmune disease related to gluten intolerance (gluten-sensitive enteropathy) (Freeman et al., 2011). It occurs in genetically susceptible individuals through the ingestion of gluten and is more frequent in women, as is also the case for many autoimmune diseases (...

OBJECTIVE Chronic inflammation with microglia activation is thought to play a major role in the formation or clearance of Alzheimer's disease (AD) lesions, as well as in the induction of demyelination in multiple sclerosis (MS). In MS, the cortex is severely affected by chronic, long-lasting inflammation, microglia activation, and demyelination. To what extent chronic inflammation in the cortex...

Simplified Pathology of NIS In MS, T cells are inappropriately activated to recognize myelin and myelin-forming cells (oligodendrocytes) as foreign which results in starting of an autoimmune process. This inappropriate immune response can cause the production of cytokines that continue to activate T cells and cause additional damage to the myelin. The first stage in the cascade leading to MS is...

Multiple sclerosis (MS) affects all aspects of a person's life. Considering the unpredictable progress of MS, Patients suffer from uncertainty about their future health and wellbeing which causes psychological distress and social degradation and consequently it affects the development of the disease. This study aims to investigate the relationship between uncertainty in the disease with the fre...

Classifications of multiple sclerosis subtypes have been largely based on clinical phenomenology. Nevertheless, definitions of relapse, remission and progression have been imprecise. Recently an international consensus group, as part of a reclassification of disease subtypes, recommended dropping the term 'relapsing-progressive' (RP) and retaining the term 'progressive-relapsing' (PR) multiple ...

vitamin d has long been speculated to reduce the risk of multiple sclerosis (ms). however, its role in development and modulating the course of ms has yet to be clarified. to date, there is no scientific evidence for the use of vitamin d as monotherapy for ms in clinical practice and perplexities still exist on potential disadvantages of vitamin d intake. we hypothesize that vitamin d may be ef...