A substantial, but uncertain, number of patients with cancer develop brain metastases. Risk of brain metastasis is recognized to vary with type of primary cancer. Within specific types of primary cancer, prognostic factors for development of brain metastases are being recognized. Recent data suggest that molecular biomarkers that relate to cellular function can predict risk of developing brain ...

Brain tumors represent the most common solid neoplasm in children and second most common pediatric malignancy overall, following leukemia. Outside of infancy, the majority of primary childhood brain tumors occur in the infratentorial compartment and include medulloblastoma, juvenile pilocytic astrocytoma (JPA), ependymoma, and brainstem/ pontine glioma; atypical teratoid rhabdoid tumor (ATRT) i...

Abstract GBM is the most common primary malignant brain tumor in adults. O6-methylguanine DNA methyltransferase (MGMT) promoter methylation status an important prognostic biomarker that predicts response to temozolomide and guides treatment decisions. At present, only reliable way determine MGMT through analysis of tissues. Given limitations complications histology-based methods, imaging-based ...