Periarticular osteolysis is a debilitating complication of inflammatory arthritis. While controversy exists as to whether pannus, itself, is capable of degrading bone, the osteoclast is clearly the principal, if not exclusive, bone resorptive cell in rheumatoid disease and other osteopenic disorders. Thus, the treatment of inflammatory osteolysis depends upon understanding the means by which th...

Aseptic loosening of total joint arthroplastics due to periprosthetic osteolysis is a frequent cause of implant failure. The absence of clinical interventions to arrest or prevent this complication limits the use of total joint replacement especially in younger patients. Here we review recent studies implicating tumor necrosis factor (TNF)-alpha in periprosthetic osteolysis and the rationale fo...

A case of exuberant acroosteolysis and subcutaneous tissue calcinosis in the absence of skin involvement is presented. Different hypotheses are discussed following the clinical unfolding of the case in practice.

Hajdu-Cheney syndrome is a rare, autosomal dominant skeletal dysplasia marked by acro-osteolysis of the distal phalanges and severe osteoporosis. Although there are more than 60 reports published to date, proper treatment and subsequent outcome have been scarce. Herein, we report a progress of anti-resorptive therapy with zoledronic acid, in a woman with Hajdu-Cheney syndrome. Results suggest t...

Polyethylene wear has been accepted as a major cause of osteolysis in total hip arthroplasty. Submicron particles, which are secondary to abrasive wear, migrate into the effective joint space and stimulate a foreign-body response resulting in bone loss which is mainly mediated by macrophages. Diagnosis depends on serial radiographic evaluation and frequent follow-up. Polyethylene wear and osteo...

Recent concern regarding the safety of recombinant human bone morphogenetic protein-2 (BMP-2) in spine surgery has increased awareness of a possible broad spectrum of adverse sequelae of this biologic. However, the impact of BMP-2 on postoperative osteolysis in the setting of lateral lumbar interbody fusion needs to be comprehensively evaluated. Three cases of significant osteolysis within the ...

Introduction: Osteolysis around orthopaedic implants, a consequence of the wear process, is a major problem for the long-term survival of the implants. We and others previously reported quantitative versions of the murine calvarial model of titanium particle induced osteolysis [1,2]. However, the most common particle type that is generated from orthopaedic implants is ultrahigh molecular weight...

Periprosthetic osteolysis is a common complication following total ankle arthroplasty (TAA). However, understanding of volume and distribution still evolving, undermining efforts to reduce the incidence via bone remodeling. We obtained data on characteristics developing within distal tibia talus after TAA. Three-dimensional computed tomography (3D-CT) reconstructions 12 patients who underwent H...

We determine the equation of state of stoichiometric FeO by employing the diffusion Monte Carlo method. The fermionic nodes are fixed by a single Slater determinant of spin-unrestricted orbitals. The calculated ambient-pressure properties (lattice constant, bulk modulus, and cohesive energy) agree very well with available experimental data. At approximately 65 GPa, the atomic lattice changes fr...

A case of rheumatoid thumb carpometacarpal (CMC) arthritis with advanced osteolysis is reported. Although CMC joint arthrodesis was performed, bone union was not achieved, and pain and instability persisted. Therefore, first and second metacarpal bone fusion was performed with satisfactory results. While CMC joint arthrodesis or arthroplasty is typically performed, first and second metacarpal b...