STUDY DESIGN Multicenter retrospective study. OBJECTIVES To investigate the risk of symptomatic recurrent laryngeal nerve palsy (RLNP) following cervical spine surgery, to examine risk factors for its development, and to report its treatment and outcomes. METHODS A multicenter study from 21 high-volume surgical centers from the AOSpine North America Clinical Research Network was performed. ...

Data from four multicenter trials1-4 indicates that hypothermia is effective in diminishing brain injury in some neonates with moderate to severe hypoxic-ischemic encephalopathy (HIE). Currently, hypothermia is emerging as a standard of care for certain neonates with HIE. Meta-analysis suggests the therapy may prevent long-term neurologic deficits in one neonate for every 8 treated.5 Since hypo...

The learning health system is a framework in which new knowledge is translated into general clinical practice and clinical practice serves as the engine to generate new evidence and knowledge. One type of learning health system is an electronic health record (EHR)-linked multicenter registry. Significant investment has been made in recent years to spur the adoption of EHRs and to fund the creat...

OBJECTIVES To evaluate the generalizability of stringent protocol-driven weaning in improving total duration of opioid treatment and length of inpatient hospital stay after treatment of neonatal abstinence syndrome (NAS). METHODS We conducted a retrospective cohort analysis of 981 infants who completed pharmacologic treatment of NAS with methadone or morphine from January 2012 through August ...

Interest in international multicenter clinical trials is increasing for a variety of reasons. Working with different cultures in clinical research creates its own unique set of problems. This paper focuses on these issues from multicenter and multicultural perspectives. The influence of culture on patient-doctor communication is considered. Expectations and the use of outcomes measurements with...

BACKGROUND/AIMS Telemedicine is a convenient and efficient tool for remote education in various fields. The telemedicine system can also be used to educate doctors and medical students. The aim of our study was to establish the effectiveness of the telemedical system for use in a live endoscopic multichannel demonstration conference and to test the effectiveness and usefulness of a multicenter-...

BACKGROUND Acute and chronic cartilage injury of the knee has an important impact on prognosis. The validity of the classification of such injuries is critical for prospective multicenter studies. The agreement among multiple surgeons at different institutions for articular cartilage lesions has not been established. HYPOTHESIS Arthroscopic classification of articular cartilage lesions is rel...

Here we investigated the establishment of multicenter cooperative treatment groups in China, as well as radiotherapy compliance and effectiveness among children with renal tumors. Medical records were reviewed for 316 children with renal tumors diagnosed by a multicenter cooperative group from 14 hospitals in China from 1998 to 2012. Median patient age was 29.5 months (range, 2-173 months old),...

Since 1982, the multicenter study of the epidemiology of patients with haemophilia is carried out annually with the support of all sizes of haemophilia centers and treatment facilities. The long period of investigation has not only enabled the reporting of up-to-date mortality and morbidity status, but also of retrospective observations. The participating centers have made anonymized data avail...

Traditional approaches and study designs in cancer epidemiology have not been very successful identifying and evaluating potential risks and/or protective factors associated with disease. Failure is often due to small study sample size and inadequate exposure information. In this paper, we discuss issues and approaches relevant to these two challenges. Multicenter study design is proposed as a ...