نتایج جستجو برای: multi drug resistance
تعداد نتایج: 1343194 فیلتر نتایج به سال:
Continuous deployment of antifungals in treating infections caused by dimorphic opportunistic pathogen Candida albicans has led to the emergence of drug resistance resulting in cross-resistance to many unrelated drugs, a phenomenon termed multidrug resistance (MDR). Despite the current understanding of major factors which contribute to MDR mechanisms, there are many lines of evidence suggesting...
Can we exploit our burgeoning understanding of molecular evolution to slow the progress of drug resistance? One role of an infection clinician is exactly that: to foresee trajectories to resistance during antibiotic treatment and to hinder that evolutionary course. But can this be done at a hospital-wide scale? Clinicians and theoreticians tried to when they proposed two conflicting behavioral ...
A Hybrid Drug Limits Resistance by Evading the Action of the Multiple Antibiotic Resistance Pathway.
Hybrid drugs are a promising strategy to address the growing problem of drug resistance, but the mechanism by which they modulate the evolution of resistance is poorly understood. Integrating high-throughput resistance measurements and genomic sequencing, we compared Escherichia coli populations evolved in a hybrid antibiotic that links ciprofloxacin and neomycin B with populations evolved in c...
A comparative genetic analysis of 42 clinical Klebsiella pneumoniae isolates, resistant to two or more antibiotics belonging to the broad-spectrum β-lactam group, sourced from Sydney, Australia, and three South American countries is presented. The study focuses on the genetic contexts of class 1 integrons, mobilizable genetic elements best known for their role in the rapid evolution of antibiot...
Antibiotic pollution has recently been a global environmental and human health concern. When bacteria are exposed to antibiotics, they express drug resistance. Drug resistance genes can be vertically and horizontally transferred in the environment. In this paper, I provide a summary of our work on one category of tetracycline resistance gene, termed ribosomal protection protein gene. In particu...
Physical drug delivery through smart nanocarrier and external stimulus could lead to significant improvements of drug potency as well as noticeable decrease in unwanted side effects. Currently, many external energy sources such as light, magnetic fields, ultrasound, ..., are under investigation as external stimulus for physical drug delivery. The purpose of this paper is to review most recent ...
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