نتایج جستجو برای: mucous membrane pemphigoid
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Bullous pemphigoid is the most common autoimmune subepidermal blistering disease of the skin and mucous membranes. This disease typically affects the elderly and presents with itch and localized or generalized bullous lesions. In up to 20% of affected patients, bullae may be completely absent, and only excoriations, prurigo-like lesions, eczematous lesions, urticated lesions and/or infiltrated ...
Autoantibodies against structural proteins of the basement membrane zone (BMZ) cause dermal-epidermal adhesion loss in pemphigoid diseases. Biopsies usually show IgG and C3 at BMZ, indicating complement (C) activation that facilitates attraction inflammatory cells blister formation. We generated 23 anti BP180 antibody (ab) clones from two bullous (BP) patients by phage display. All ab were vali...
Pemphigoid gestationis (PG), first described in 1872 by Laws Milton, is a rare autoimmune bullous disease of pregnancy and puerperium. Pemphigoid gestationis has been estimated to occur in 1: 50 000 pregnancies and usually presents in the second or third trimester with exacerbation after partum. This disease is caused by circulating IgG1 immunoglobulin against hemidesmosomal protein bullous pem...
BACKGROUND Immunofluorescence testing is an important tool for diagnosing blistering diseases. OBJECTIVE To characterize the immunofluorescence findings in patients diagnosed with autoimmune blistering skin diseases. METHODS We retrospectively analyzed immunofluorescence results encompassing a 10-year period. RESULTS 421 patients were included and divided into 2 groups: group 1- intraepid...
A 20 year old woman died of respiratory failure due to cicatricial pemphigoid of the trachea and bronchi. This is the first case with the lower airways affected to be reported.
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