Objective(s): Staphylococcus epidermidis is a common cause of medical device-associated infections due to biofilm formation, and its elimination is extremely challenging. Although rifampin efficacy against S. epidermidis biofilms has been confirmed, its use as a single agent may lead to resistance. As such, it is assumed that the combination of rifampin and N-acetylcysteine (NAC) could exert ad...

The antifungal effect and mucolytic activity of a newly screened biocontrol strain Chaetomium subaffine LB-1 were researched in this study. results found that has good effects on the test plant pathogenic fungi Botrytis cinerea Pers. ex Fr., Fusarium oxysporum f. sp. cucumerinum Owen Alternaria solani (Ellis & Martin) Sorauer dual culture assay, with inhibition rates 61.39, 50.34 51.22%, respec...

Conjugation of recombinant human deoxyribonuclease I (rhDNase) to polyethylene glycol (PEG) 20 40 kDa was previously shown prolong the residence time rhDNase in lungs mice after pulmonary delivery while preserving its full enzymatic activity. This work aimed study fate native and PEGylated elucidate their biodistribution elimination pathways intratracheal instillation mice. In vivo fluorescence...

Bromelain is a mixture of proteolytic enzymes that extracted primarily from pineapples. It present in almost all the aerial parts plant—the peels, leaves, stems and fruit—although only fruit contain significant amounts. The market-demand for bromelain quickly increasing, especially health sector as it can be used drug and/or nutraceutical. Although complete molecular mechanism has not been full...

N-acetylcysteine (NAC) is an anti-oxidant drug that has been used as a mucolytic agent and a paracetamol antidote for many years. This study was designed to determine the efficacy of the adjunctive use of NAC for periodontal treatment. Thirty subjects with moderate-to-severe chronic periodontitis were randomized to surgery with NAC (600 mg; S-NAC), surgery only (S-nonNAC), and healthy control g...