Abstract Background The mucus network provides innate immune defense to protect our gastrointestinal tract from pathogens, and promote homeostasis with resident microbiota. This is constituted by the mucin MUC2 (Muc2 in mouse), which ~80% complex O-linked glycans weight. Sialic acid (Sia) a key capping monosaccharide on O-glycans has recently been linked preserving integrity. Sia can undergo en...

Perianal Paget's disease (PPD) represents a skin neoplasm which can be either primary or secondary to carcinoma from an adjacent internal organ. PPD with underlying colorectal adenocarcinoma is usually looked upon as a secondary disease. We report a rare case of co-associated PPD and anorectal adenocarcinoma. The PPD was found to be located near the anorectal adenocarcinoma with normal tissues ...

The MUC2 mucin is the major constituent of the two mucus layers in colon. Mice lacking the disulfide isomerase-like protein Agr2 have been shown to be more susceptible to colon inflammation. The Agr2(-/-) mice have less filled goblet cells and were now shown to have a poorly developed inner colon mucus layer. We could not show AGR2 covalently bound to recombinant MUC2 N- and C-termini as have p...

Intestinal and skin microflora can influence several systemic health behaviors. In this study, we hypothesized that gut tissue microbiota are linked, control the microbiota. To test this, compared intestinal responses in mice to co-housed littermates with full-thickness incisions on back or K14Cre-targeted expression of HYAL-1 epidermis. The latter represent a skin-specific model hyaluronidase ...

Siendo el cáncer gástrico la 3ª causa de muerte por en Chile, y existiendo estrategias tamizaje consistentes pesquisa lesiones preneoplásicas mucosa gástrica, es relevante conocer los aspectos genéticos moleculares que puedan ser aplicados, optimización dichas a grupos mayor riesgo. El objetivo este manuscrito fue revisar evidencia actual señalados, inmunohistoquímica 4 marcadores (p53...

We have identified intracellular targets that are affected by vitamin D in intestinal epithelial cells in two ways: analyzing profiles of gene expression in a matrix of dietary-genetic interactions in mouse models, and exploring a novel mechanism of transcriptional attenuation. Genetic models of intestinal cancer in the mouse models included inheritance of a mutation in the Apc gene (Apc1638N /...