Abstract Immunosuppressive ability in human MSC donors has been shown to be variable and may a limiting factor therapeutic efficacy vivo. The importance of cytokine activation mesenchymal stromal cells (MSCs) facilitate their immunosuppressive function is well established. This study sought further understand the interactions between MSCs commonly used calcineurin inhibitor cyclosporine A (CsA)...

BACKGROUND Mesothelial cell injury plays an important role in peritoneal fibrosis. Present clinical therapies aimed at alleviating peritoneal fibrosis have been largely inadequate. Mesenchymal stem cells (MSCs) are efficient for repairing injuries and reducing fibrosis. This study was designed to investigate the effects of MSCs on injured mesothelial cells and peritoneal fibrosis. METHODOLOGY...

Background In recent years, increasing attention has been paid to the effects of low-dose irradiation on human health. We examined whether low-dose irradiation affected the functions of mesenchymal stromal/stem cells (MSCs), which are tissue/organ-supportive stem cells, derived from bone marrow (BM). Methods Normal human BM-MSCs from five healthy individuals were used in this study. Culture-e...

Human amniotic membrane-derived mesenchymal stem cells (hAM-MSCs) are capable of differentiating into several lineages and possess immunomodulatory properties. In this study, we investigated the soluble factor-mediated immunomodulatory effects of hAM-MSCs. Mitogen-induced peripheral blood mononuclear cell (PBMC) proliferation was suppressed by hAM-MSCs in a dose-dependent manner as well as hAM-...

The rapid development of wearable electronics has stimulated the urgent demand for compatible, miniaturized energy storage devices. As one most promising candidates, micro-supercapacitors (MSCs) have attracted significant attention, owing to their high power densities, long operation life, and fast charge/discharge rate. In comparison conventional, rigid MSCs, deformable MSCs are attracting mor...

Message Sequence Charts (MSCs) are a graphical and textual language for the spec-iication of message passing systems, in particular telecommunication systems. MSCs are standardised by the Internal Telecommunication Union in standard Z.120. Included in the standard is a formal semantics for MSCs by means of a process algebra. This semantics covers the complete language of single MSCs but lacks a...

Message Sequence Charts MSCs are a graphical and textual language for the speci cation of message passing systems in particular telecommunication systems MSCs are standardised by the Internal Telecommunication Union in standard Z Included in the standard is a formal semantics for MSCs by means of a process algebra This semantics covers the complete language of single MSCs but lacks an interpret...

Message Sequence Charts (MSCs) are a graphical and textual language for the speciication of message passing systems, in particular telecommunication systems. MSCs are standardised by the Internal Telecommunication Union in standard Z.120. Included in the standard is a formal semantics for MSCs by means of a process algebra. This semantics covers the complete language of single MSCs but lacks an...

Maternal obesity increases the risk for pediatric obesity; however, the molecular mechanisms in human infants remain poorly understood. We hypothesized that mesenchymal stem cells (MSCs) from infants born to obese mothers would demonstrate greater potential for adipogenesis and less potential for myogenesis, driven by differences in β-catenin, a regulator of MSC commitment. MSCs were cultured f...

Mesenchymal stem cells (MSCs) isolated from bone marrow (BM), cartilage, and adipose tissue (AT) possess the capacity for self-renewal and the potential for multilineage differentiation, and are therefore perceived as attractive sources of stem cells for cell therapy. However, MSCs from these different sources have different characteristics. We compared MSCs of adult Sprague Dawley rats derived...