OBJECTIVE To assess the feasibility and reliability of apparent diffusion coefficient (ADC) measurements of normal adrenal glands. MATERIALS AND METHODS This was a retrospective study involving 32 healthy subjects, divided into two groups: prepubertal (PreP, n = 12), aged from 2 months to 12.5 years (4 males; 8 females); and postpubertal (PostP, n = 20), aged from 11.9 to 61 years (5 males; 1...

Despite several previous attempts, histological validation of diffusion-weighted magnetic resonance imaging (DW-MRI)-based tractography as true axonal fiber pathways remains difficult. In the present study, we establish a method to compare histological and tractography data precisely enough for statements on the level of single tractography pathways. To this end, we used carbocyanine dyes to tr...

OBJECTIVES This study sought to analyze the impact of new asymptomatic cerebral ischemic lesions, found in diffusion-weighted magnetic resonance imaging (DW-MRI) after carotid artery stenting (CAS) in relation to other risk factors for major adverse cerebral and cardiovascular events (MACCE) defined as death, stroke, and myocardial infarction. BACKGROUND After CAS, new cerebral lesions have b...

OBJECTIVE To investigate the role of apparent diffusion coefficient (ADC) from diffusion-weighted magnetic resonance imaging (DW-MRI) when applied to the 7th TNM classification in the staging and prognosis of gastric cancer (GC). METHODS Between October 2009 and May 2014, a total of 89 patients with non-metastatic, biopsy proven GC underwent 1.5T DW-MRI, and then treated with radical surgery....

This work provides a framework for modeling and extracting the Cingulum Bundle (CB) from Diffusion-Weighted Imagery (DW-MRI) of the brain. The CB is a tube-like structure in the brain that is of potentially of tremendous importance to clinicians since it may be helpful in diagnosing Schizophrenia. This structure consists of a collection of fibers in the brain that have locally similar diffusion...

Apparent diffusion coefficient (ADC) values derived from diffusion-weighted magnetic resonance imaging (DW-MRI) are known to reflect the cellular environment of biological tissues. However, emerging evidence accentuates the influence of stromal elements on ADC values. The current study sought to elucidate whether a correlation exists between ADC and the fraction of collagen I-positive tissue ac...

Introduction Diffusion Weighted MRI (DW-MRI) of the brain is based on signal attenuation that originates from multiple morphological or functional sources [1]. Recently it was also suggested that some of these mechanisms can be used to detect neuronal activity directly by DW-MRI [2]. The quantification of the relative contribution of these physical factors to the DW-MRI signal in-vivo (in healt...

We report longitudinal diffusion-weighted magnetic resonance imaging (DW-MRI) and dynamic contrast enhanced (DCE)-MRI (7 T) studies designed to identify functional changes, prior to volume changes, in trastuzumab-sensitive and resistant HER2+ breast cancer xenografts. Athymic mice (N = 33) were subcutaneously implanted with trastuzumab-sensitive (BT474) or trastuzumab-resistant (HR6) breast can...

Targeted chemotherapeutic agents often do not result in tumor shrinkage, so new biomarkers that correlate with clinical efficacy are needed. In this study, we investigated noninvasive imaging protocols to monitor responses to sorafenib, a multikinase inhibitor approved for treatment of renal cell and hepatocellular carcinoma. Healthy cells are impermeable to fumarate, so conversion of this meta...

Diffusion Weighted Magnetic Resonance Imaging (DW-MRI) is a recent modality to investigate the major neuronal pathways of the human brain. However, the rich DW-MRI datasets cannot be interpreted without proper preprocessing. In order to achieve understandable visualizations, this dissertation reduces the complex data to relevant features. The first part is inspired by topological features in fl...