نتایج جستجو برای: mps

تعداد نتایج: 4974  

2010
Chiara Porro Silvia Lepore Teresa Trotta Stefano Castellani Luigi Ratclif Anna Battaglino Sante Di Gioia Maria C Martínez Massimo Conese Angela B Maffione

BACKGROUND Microparticles (MPs) are membrane vesicles released during cell activation and apoptosis. MPs have different biological effects depending on the cell from they originate. Cystic fibrosis (CF) lung disease is characterized by massive neutrophil granulocyte influx in the airways, their activation and eventually apoptosis. We investigated on the presence and phenotype of MPs in the sput...

2016
Fariborz Mobarrez Anna Vikerfors Johanna T. Gustafsson Iva Gunnarsson Agneta Zickert Anders Larsson David S. Pisetsky Håkan Wallén Elisabet Svenungsson

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by circulating autoantibodies and the formation of immune complexes. In these responses, the selecting self-antigens likely derive from the remains of dead and dying cells, as well as from disturbances in clearance. During cell death/activation, microparticles (MPs) can be released to the circulation. Previous M...

Journal: :Blood 2013
Julia E Geddings Nigel Mackman

Patients with cancer have an increased risk for venous thrombosis. Interestingly, different cancer types have different rates of thrombosis, with pancreatic cancer having one of the highest rates. However, the mechanisms responsible for the increase in venous thrombosis in patients with cancer are not understood. Tissue factor (TF) is a transmembrane receptor and primary initiator of blood coag...

Journal: :Blood 1995
M S Sands L C Erway C Vogler W S Sly E H Birkenmeier

MPS VII mice are deficient in beta-glucuronidase and share many clinical, biochemical, and pathologic characteristics with human mucopolysaccharidosis type VII (MPS VII). We have shown that syngeneic bone marrow transplantation (BMT) prolongs survival and reduces lysosomal storage in many organs of the MPS VII mouse. In this report, we quantify the hearing loss and determine the impact of synge...

2016
Liza Grosman-Rimon William Parkinson Suneel Upadhye Hance Clarke Joel Katz John Flannery Philip Peng Dinesh Kumbhare

The aims of the present study were to compare levels of circulating inflammatory biomarkers and growth factors between patients with myofascial pain syndrome (MPS) and healthy control participants, and to assess the relationship among inflammatory markers and growth factors in the two groups.Biomarkers levels were assessed in patients (n = 37) with myofascial pain complaints recruited from the ...

2013
Jung-Joon Cha Jong-Youn Kim Eui-Young Choi Pil-Ki Min Minhee Cho Da-Lyung Lee Sung-Yu Hong Young-Won Yoon Byoung Kwon Lee Bum-Kee Hong Se-Joong Rim Hyuck Moon Kwon

BACKGROUND AND OBJECTIVES We investigated the effect of the additional use of abciximab during percutaneous coronary intervention (PCI) on the level of procoagulant microparticles (MPs) in patients with ST-segment elevation myocardial infarction (STEMI) who had undergone primary PCI. SUBJECTS AND METHODS In this study, we studied 86 patients with STEMI (72 men, age 58±13) who had undergone pr...

2017
Ainslie L K Derrick-Roberts Matilda R Jackson Carmen E Pyragius Sharon Byers

Mucopolysaccharidosis type I (MPS I) is the most common form of the MPS group of genetic diseases. MPS I results from a deficiency in the lysosomal enzyme α-l-iduronidase, leading to accumulation of undegraded heparan and dermatan sulphate glycosaminoglycan (GAG) chains in patient cells. MPS children suffer from multiple organ failure and die in their teens to early twenties. In particular, MPS...

Journal: :Blood 2015
Stéphane M Camus João A De Moraes Philippe Bonnin Paul Abbyad Sylvain Le Jeune François Lionnet Laurent Loufrani Linda Grimaud Jean-Christophe Lambry Dominique Charue Laurent Kiger Jean-Marie Renard Claire Larroque Hervé Le Clésiau Alain Tedgui Patrick Bruneval Christina Barja-Fidalgo Antigoni Alexandrou Pierre-Louis Tharaux Chantal M Boulanger Olivier P Blanc-Brude

Intravascular hemolysis describes the relocalization of heme and hemoglobin (Hb) from erythrocytes to plasma. We investigated the concept that erythrocyte membrane microparticles (MPs) concentrate cell-free heme in human hemolytic diseases, and that heme-laden MPs have a physiopathological impact. Up to one-third of cell-free heme in plasma from 47 patients with sickle cell disease (SCD) was se...

2017
Kevin D. Tipton

• The metabolic basis for changes in muscle mass is net muscle protein balance, i.e., the balance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB). Changes in MPS are responsible for a much greater proportion of the change in net muscle protein balance than are changes in MPB. • Many factors influence the response of MPS to protein ingestion following resistance exercis...

2017
Yuchen Zhang Junjun Cheng Fang Chen Changyan Wu Junmeng Zhang Xuejun Ren Yu Pan Bin Nie Quan Li Yu Li

Microparticles (MPs) and miRNAs have been shown to play important roles in coronary artery disease (CAD) by monitoring endothelial dysfunction. The present study aims to investigate the diagnostic value of endothelial MPs (EMPs) and miRNAs (miR-92a or miR-23a) as biomarkers in distinguishing patients with acute myocardial infarction (AMI) from those with CAD. Plasma samples from 37 patients wit...

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