1. Intracellular recordings were obtained from 149 motoneurons innervating triceps surae (n = 109) and more distal muscles (n = 40) in 14 pentobarbital-anesthetized monkeys (Macaca nemestrina). The variables evaluated were resting membrane potential, action potential amplitude, conduction velocity (CV), input resistance (RN), membrane time constant (tau m), electrotonic length (L), whole-cell c...

Hypothesis / aims of study Duloxetine and reboxetine are two drug that inhibit reuptake of norepinephrine and increase norepinephrine levels in the central nervous system. Both drugs have shown clinical efficacy in the treatment of stress urinary incontinence (1). It is still unclear, however, how increases in norepinephrine can modulate urethral sphincter activity. Spinal motoneurons of Onuf’s...

Previous work has demonstrated that Lambert-Eaton syndrome (LES) antibodies reduce calcium currents in nonneuronal cells and neurons and reduce the amplitude of extracellularly recorded currents at mouse motor nerve terminals. We compared effects of LES sera on whole-cell currents of cultured nerve and muscle. LES sera more strongly reduced calcium currents in motoneurons than in sensory neuron...

background and aims: neurons are injured under physical, chemical and pathological conditions. the effect of peripheral nervous system injuries may return as retrograde to the cell body of neurons in central nervous system resulting in brain and spinal cord degeneration. because of high content of camphor and borneol, achillea biebersteinii from asteracea family may be effective in prevention t...

In many animals, limb movements transition between gait patterns with increasing locomotor speed. While for tetrapod systems several well-developed models in diverse taxa (e.g., cat, mouse, salamander, turtle) have been used to study motor control of limbs and limb gaits, virtually nothing is known from fish species, including zebrafish, a well-studied model for axial motor control. Like tetrap...

Introduction Spinal cord injury (SCI) is a debilitating condition that disrupts the communication between brain and spinal cord. Several studies have sought to determine how revive dormant circuits caudal lesion restore movements in paralyzed patients. So far, recovery levels human patients been modest at best. In contrast, animal models of SCI exhibit more lost function. Previous work from our...

It has been shown in the rat, that during the first five postnatal days, motoneurons are particularly vulnerable to excitotoxic cell death and glutamate receptors play a significant role in this time-dependent process. Various categories of glutamate blockers (MK-801, Mg, PNQX, DAP-5) have various actions on the respective receptors. Furthermore, the different response between mature and immatu...

Death pathways restricted to specific neuronal classes could potentially allow for precise control of developmental neuronal death and also underlie the selectivity of neuronal loss in neurodegenerative disease. We show that Fas-triggered death of normal embryonic motoneurons requires transcriptional upregulation of neuronal NOS and involves Daxx, ASK1, and p38 together with the classical FADD/...

The present study examined the effects of strychnine on the tonic hyperpolarization and the changes in membrane properties of lumbar motoneurons that occur during active sleep. To carry out these studies, intracellular recordings from lumbar motoneurons were combined with the juxtacellular microiontophoretic application of strychnine in chronic, undrugged, normally respiring cats. During active...