PreDREM is a database of DNA regulatory motifs and motifs modules predicted from DNase I hypersensitive sites in 349 human cell and tissue samples. It contains 845-1325 predicted motifs in each sample, which result in a total of 2684 non-redundant motifs. In comparison with seven large collections of known motifs, more than 84% of the 2684 predicted motifs are similar to the known motifs, and 5...

seals and clay sealings are the most important cultural material of sasanian period. there have been a few seals and bullas of various periods retained in the moghadam museum of tehran. these materials have not been introduced so far. authors of the present paper aim at to study and introduce the sasanian seals and bullas of this museum especially those bearing animal symbolic motifs. we do thi...

the interactions between southeastern sites of iranian plateau and western sites in susa and mesopotamia in the third millennium b.c is one of the most controversial aspects of the near eastern archaeology. it seems that with some structural changes in these sites from the middle of 4th millennium b.c that led to long distance trade between mesopotamia and indus valley, these sites were related...

Identification of cis-regulatory motifs has long been a hotspot in the study of alternative splicing. We propose a two-step approach: we first identify k-mer seed motifs by testing for enrichment and significant differences in exon skipping rate, then a local stochastic search is applied to refine the seed motifs. Our approach is especially suitable to discover short and degenerate motifs. We a...

Comprehensive motif discovery under experimental conditions is critical for the global understanding of gene regulation. To generate a nearly complete list of human DNA motifs under given conditions, we employed a novel approach to de novo discover significant co-occurring DNA motifs in 349 human DNase I hypersensitive site datasets. We predicted 845 to 1325 motifs in each dataset, for a total ...