Curcumin has been found to be very efficacious against many different types of diseases. However, the major disadvantage associated with the use of curcumin is its low systemic bioavailability. In the present study the protective effects of curcumin-loaded poly lactic-co-glycolic acid nanoparticles (nanocurcumin) against mono-iodoacetate-induced osteoarthritis in rats was investigated. Mono-iod...

The inactivation of beef liver porphobilinogen synthase by the alkylating agents iodoacetate and iodoacetamide has been investigated. The synthase can be inactivated by these reagents only if the enzyme has been activated initially by sulfhydryl reducing agents. Inactivation by both iodoacetate and iodoacetamide was the result of modification of cysteinyl residues. A plot of the incorporation o...

BACKGROUND Monosodium glutamate (MSG) is a commonly used food additive and there is growing concern that excitotoxins such as MSG play a critical role in the development of several hepatic disorders. OBJECTIVES The histochemical effect of monosodium glutamate was investigated on the liver of adult Wistar rats. METHODS Adult male Wistar rats (n = 24), with an average weight of 230 g were ran...

Feeding behavior is regulated by feeding-related peptides in the hypothalamus. The neurons of the arcuate nucleus (ARC), which produces feeding-related peptides, develop and function by three weeks of age in rodents. Because rodents are weaned at three weeks, we studied whether the process of weaning is involved in the development of ARC neurons using monosodium glutamate. Rat pups injected neo...

Transmission electron microscopic studies of synthetic and natural monosodium urate crystals dried on formvar coated grids showed identical internal structures in all crystals. At higher magnification the crystals' surface showed angular or wavy irregularities, and more rarely some crystals appeared to have other tiny crystals on the surface. Protein-like surface coating was not observed except...

IT is now well established that retinal degeneration can be produced in several species of laboratory animals by intravenous injection of sodium iodoacetate (Schubert and Bornschein, 1951; Noell, 1952; Berardinis, 1953; Karli, 1954; Rabinovitch, Mota, and Yoneda, 1954; Babel and Ziv, 1956). Thus, Noell (1952) described a destruction of the visual cells in rabbits, cats, and monkeys after repeat...