Extensive use of monoamine oxidase inhibitors and imipramine in psychiatric practice has revealed serious toxic reactions. It has been observed that combination of monoamine oxidase inhibitor and imipramine produces a symptom complex characterized by hyperexcitement, motor restlessness and hyperpyrexia (1-6). Furthermore, hypertensive crisis, subarachnoid haemorrhage and pulmonary oedema has be...

22 Effect of Costus speciosus and Wedelia chinensis on Brain Neurotransmitters and Enzyme Monoamine Oxidase Following Cold Immobilization Stress Nitin Verma * and R .L. Khosa Pharmacognosy and Phytochemistry Division, Department of Pharmacy, Bharat Institute of Technology, Partapure Bypass Road Meerut250103, U.P. India ____________________________________________________________________________...

Most of the actions of sex hormones are mediated by specific cytosolic receptors in target tissues, translocating to the cell nucleus where they exert their effects (Buller & O'Malley, 1976; McEwen ef al., 1978). An effective means of monitoring changes in gene products resulting from hormonal stimulation is to measure enzyme activities in target tissues (McEwen et al., 1978). Sex steroids affe...

The effect of alloxan diabetes on the activity of monoamine oxidase was studied in three regions of the rat brain at various time intervals after the onset of diabetes. It was observed that monoamine oxidase activity was decreased at early time intervals after diabetes, followed by a recovery in all three regions of the brain. A reversal of the effect was observed with insulin administration to...