tranexamic acid is generally used in the treatment of disorders that predispose one to bleeding. it is a synthetic lysine analog that has strong antifibrinolytic activity. plasminogen binds to fibrin to form plasmin, which in turn degrades fibrin into fibrin degradation products. tranexamic acid blocks the lysine binding site on plasminogen and prevents interaction with fibrin. tranexamic acid ...

the mechanism by which bi-and trivalent cations affect human liver phosphatidatephosphohydrolase (pap) activity was investigated. bivalent cations up to 1 mm increased pap activity whereas at higher concentrations the activity of the enzyme decreased. the stimulatory concentration for trivalent cations such as al3+ and cr3+, however, was much lower being 2 m m and 1 m m, respectively. all catio...

background and purpose: the relationship between uric acid and stroke recurrence is ambiguous. some studies have explored this relationship in acute ischemic stroke but had different results. we evaluated the association of admission uric acid level with risk of stroke recurrence in patients with ischemic stroke. methods: we studied ischemic stroke patients presenting to our hospital with magne...

sugarcane bagasse contains cellulose, lignin and hemicellulose, 39-42%, 20-25% and 25-27% respectively. so it is can be used as a sugar source in many processes. lignin and hemicellulose must be removed before hydrolysis of cellulose. several different pretreatment approaches have been studied. the purpose of this research is comparison of acid, ozone and combination of ozone-acid as pretreatme...

we have investigated the preventive effects of oral administration of isolated e.coli ghttam'tc acid decarboxylase (gad) in animal models. based on our results, the blood glucose levels were reduced by oral administration of gad to rats 14 days before intraperitoneal injections of streptozocin (40 mg/kg on five consecutive days). on the other hand, oral administration of gad to rats before stre...

phosphatidate phosphohydrolase (pap2b, fraction b) was purified from the plasma membrane ofrat liver cells. the km for the surface concentration of phosphatidic acid was 0.43 mol%. the subunit of theenzyme had an m.w. of 33.8 kda using sodium dodecyl sulfate polyacrylamide gel electrophoresis. thenative enzyme shows a molecular weight of 182 kda in a gel filtration column packed with sephacryl ...

background: white button mushroom (agaricus bisporus) is a sensitive agricultural crop whose antioxidant properties are decreased during postharvest storage. in this study, the effect of citric acid dipping treatment on bioactive components and antioxidant properties of sliced button mushroom (agaricus bisporus) was investigated. methods: fresh mushrooms soaked in chilled citric acid solution a...

this study was conducted to investigate the correlation between lipid-lowering and bone-protective effects of eicosapentaenoic acid on steroid-induced bonechanges in rats. twenty-one male 10-week-old wistar rats were divided into 3 groups (n = 7 each) and treated with 0.9% nacl sc (group 1) or methylprednisolone 7 mg/kg sc once a week (group 2) or methylprednisolone 7 mg/kg sc once a week + eic...

this study examined the effects of a protein rich diet on coping neurotransmitter levels in orally administered ampicillin–induced neurotoxic rats compared with propionic acid (pa) models of autism. 40 young male western albino rats were divided into four groups. the first group served as control and received phosphate buffered saline orally; the second group serving as autistic model was treat...