Molten globules are partially folded states of proteins which are generally believed to mimic structures formed during the folding process. In order to determine the minimal requirements for the formation of a molten globule state, we have prepared a set of peptide models of the molten globule state of human alpha-lactalbumin (alphaLA). A peptide consisting of residues 1-38 crosslinked, via the...

Previous NMR studies have shown that many phospholipase A2 (PLA2, from bovine pancreas, overexpressed in Escherichia coli) mutants display some properties reminiscent of a molten globule state. Further NMR analyses for some of the mutants indicated that formation of the "molten globule-like state" is a pH-dependent phenomenon. The mutants I9Y and I9F showed perturbed NMR properties throughout t...

Thin layers of pyroglutamic acid (Pygl) have been deposited by thermal evaporation of the molten L-glutamic acid (L-Glu) through intramolecular lactamization. This deposition was carried out with the versatile handmade low-vacuum coater, which was simply composed of a soldering iron placed in a vacuum degassing resin chamber evacuated by an oil-free diaphragm pump. Molecular structural analyses...

Moving away from conventional solid oxide electrolytes, hybrid fuel cells based on composite electrolytes (a solid oxide electrolyte and a molten alkaline carbonate phase) exhibit promising performance due to the high electrolyte conductivity within the so-called intermediate temperature ranges (400-600 C). These electrolytes are a blend of those traditionally used in Solid Oxide and Molten Car...

Gao and Sonin (1994) have proposed a method for rapid prototyping and microfabrication by precise deposition and solidification of molten microdrops. Objects can be fabricated by a drop-on-demand, computer-controlled droplet generator. To understand the fundamentals of droplet deposition and solidification, experiments have been conducted using microcrystalline wax droplets (Schiaffino and Soni...

A noncontact measurement technique for the density and the thermal expansion coefficient of refractory materials in their molten as well as solid phases is presented. This technique is based on the video image processing of a levitated sample. Experiments were performed using the high-temperature electrostatic levitator ~HTESL! at the Jet Propulsion Laboratory in which 2–3 mm diam samples can b...

1359-0286/$ see front matter 2012 Elsevier Ltd. A http://dx.doi.org/10.1016/j.cossms.2012.04.002 ⇑ Corresponding author. E-mail address: [email protected] (L.F. Nazar). Owing to almost unmatched volumetric energy density, Li-ion batteries have dominated the portable electronics industry and solid state electrochemical literature for the past 20 years. Not only will that continue, but they ar...

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