In eukaryotic cells, the ribosome-Sec61 translocon complex (RTC) establishes membrane protein topology by cotranslationally partitioning nascent polypeptides into the cytosol, ER lumen, and lipid bilayer. Using photocrosslinking, collisional quenching, cysteine accessibility, and protease protection, we show that a canonical type II signal anchor (SA) acquires its topology through four tightly ...

This paper presents a new method of predicting the liquid crystalline behavior of some organic compounds, using feed-forward neural networks. The prediction of properties is correlated with molecular weight and a series of structural characteristics estimated by mechanical molecular simulation. An efficient genetic algorithm based method is used to determine optimal topology of the neural model.

in this paper, we generalize fuzzy banach contraction theorem establishedby v. gregori and a. sapena [fuzzy sets and systems 125 (2002) 245-252]using notion of altering distance which was initiated by khan et al. [bull. austral.math. soc., 30(1984), 1-9] in metric spaces.

For reliability-based topology optimization (RBTO) of double layer grids, a two-stage optimization method is presented by applying “Solid Isotropic Material with Penalization” and “Ant Colony Optimization” (SIMP-ACO method). To achieve this aim, first, the structural stiffness is maximized using SIMP. Then, the characteristics of the obtained topology are used to enhance ACO through six modific...

Chemists have long been intrigued by the molecular basis of isomerism. Indeed, much of the powerful paradigm of structure based upon the molecular graph was first invented to explain isomerism, including the classifications used in modern stereochemistry. Thus, constitutional isomers describe pairs of isomeric molecular structures possessing non-homeomorphic molecular graphs, while the classica...

In this paper, a rational Bézier surface is proposed as a uniform approach to modeling all three types of molecular surfaces (MS): the van der Waals surface (vdWS), solvent accessible surface (SAS) and solvent excluded surface (SES). Each molecular surface can be divided into molecular patches, which can be defined by their boundary arcs. The solution consists of three steps: topology modeling,...

We consider the transitive linear maps on the operator algebra $B(X)$for a separable Banach space $X$. We show if a bounded linear map is norm transitive on $B(X)$,then it must be hypercyclic with strong operator topology. Also we provide a SOT-transitivelinear map without being hypercyclic in the strong operator topology.

Part III The Mobius Stnp Approach to Synthesis of Topologtcal Stereolsomers A Briuds and wreaths B The Mabms stnp approach 1 The THYME polyethers 2 Total synthesis of the first molecular MBbms stnp 3 Topology of the molecular MBbms stnp the MBbms ladders 4 Topological chlrahty of the MBbms ladder with three dtierentlated rungs 5 Breaking the rungs of a MGbms ladder C Synthesis of molecular knots

The imprinting factors of the β-lactam antibiotics penicillin V, methicillin, nafcillin, oxacillin, cloxacillin, dicloxacillin, and piperacillin on a poly(methacrylic acid-co-trimethylolpropane trimethacrylate) molecularly imprinted stationary phase targeted for penicillin G were correlated with molecular descriptors obtained by molecular computation. One-parameter linear regression and multiva...