In this study, syntheses of new pyrimidine-coupled N-ß-glucosides and tetra-O-acetyl derivatives were carried out. All glycoconjugates investigated in comparison with known chemotherapeutic agents terms their antimicrobial anticancer functions DNA/protein binding affinities. Spectral data showed that all glycoside obtained by diastereoselectivity as ß-anomers. Both tested groups exhibited stron...