This chapter studies an approach to establish a formal connection between data models, in particular between conceptual data models and implementation data models. We use metamodeling techniques based on the Meta Object Facility MOF. MOF may be regarded as a subset of the Unified Modeling Language UML. As prominent example data models, we formally describe and thereby analyze the EntityRelation...

Abstract: Recently, the application of the MDA to Web services has received considerable attention. In the MDA, models are instances of the MOF based metamodels. Model Transformation, which is a key feature of the MDA, can carried out via defining Transformation Rules between two MOF compliant metamodels. As a result, finding MOF compliant metamodels for languages is an essential prerequisite f...

Systemic and local inflammatory processes have a key, mainly detrimental role in the pathophysiology of ischemic stroke. Currently, little is known about endogenous counterregulatory immune mechanisms. We examined the role of the key immunomodulators CD4+CD25+ forkhead box P3 (Foxp3)+ regulatory T lymphocytes (Treg cells), after experimental brain ischemia. Depletion of Treg cells profoundly in...

BACKGROUND The aim of this study was to assess the incidence of organ failure in trauma patients treated in an intensive care unit (ICU), and to study the relationship between organ failure and long-term survival and functional status. METHODS This is a cohort study of all adult ICU trauma patients admitted to a university hospital during 1998 to 2003. Organ failure was quantified by the Sequ...

The potential for discriminating between analytes by their unique vibrational signature makes surface-enhanced Raman scattering (SERS) extremely interesting for chemical detection. However, for molecules that weakly adsorb to non-functionalized plasmonic materials, detection by SERS remains a key challenge. Here we present an approach to SERS-based detection where a polycrystalline metal-organi...

Separation of carbon dioxide and methane is an important issue in upgrading low-quality natural gas. Adsorption equilibria and kinetics of CO(2) and CH(4) on a copper metal-organic framework (MOF), Cu(hfipbb)(H(2)hfipbb)(0.5) [H(2)hfipbb=4,4'-(hexafluoroisopropylidene) bis(benzoic acid)], were investigated to evaluate the feasibility of removing CO(2) from CH(4) in a pressure swing adsorption p...

Objectives: This report explores the possibility of synthesizing enzyme–metal–organic framework (MOF) composites by ink-jet printing. Results: This study demonstrates that the direct synthesis of patterned enzyme–metal–organic framework (MOF) composites on various substrates including paper and polymeric films can be readily achieved by ink-jet printing bio-inks containing protein molecules, me...

Molecular simulations and NMR relaxometry experiments demonstrate that pure benzene or xylene confined in isoreticular metal-organic frameworks (IRMOFs) exhibit true vapor-liquid phase equilibria where the effective critical point may be reduced by tuning the structure of the MOF. Our results are consistent with vapor and liquid phases extending over many MOF unit cells. These results are count...