Background:Cardiac rehabilitation program (CRP) is a useful method of modifying cardiovascular risk factors, improving life expectancy and quality of life in patients with ischemic heart disease (IHD). The present study was conducted to evaluate the effects of cardiac rehabilitation on the pulmonary artery systolic pressure (PASP) and left ventricular end-diastolic pressure (LV...

BACKGROUND There are no disease-modifying treatments for dementia. There is also no consensus on disease modifying outcomes. We aimed to produce the first evidence-based consensus on core outcome measures for trials of disease modification in mild-to-moderate dementia. METHODS AND FINDINGS We defined disease-modification interventions as those aiming to change the underlying pathology. We sys...

background: disease-modifying drugs (dmds) are a significant expenditure for treating multiple sclerosis (ms). however, there is limited report on assessment of the cost-utility of dmds compared with symptom management in the presence of long-term data. this study aimed to assess the lifetime cost-utility from the iranian healthcare perspectives of 4dmds relative to symptom management alone in ...

: Breast cancer is one of the most common malignancy in Chinese women. Up to 80% patients with metastatic breast develop bone metastasis resulting local destruction and skeletal-related events such as pathological fracture spinal cord compression. Skeletal-related pose an enormous impact on patients' motor function quality life. Therefore, prevention treatment objectives metastasis, which often...

Life satisfaction is widely thought important—so important that many identify it with, or think it central to, happiness. But three problems undermine its significance. Most importantly, our evaluations of our lives are inherently arbitrary, so that life satisfaction’s importance as a verdict on one’s life is dubious. Second, most people appear not to have, or need, well-defined attitudes of li...

The multifunctionality of the city covers in its development all subsystems, modifying them throughout life cycles. It is difficult to stop this process, but it possible reduce anthropogenic and man-made stresses. For this, according authors article, necessary model electronic resource urban (territorial) information analytical space containing up-to-date data, which will allow on basis key pri...