Epigenetic regulation of gene expression is a process driven by dynamic changes in chromatin architecture carried out by histone-modifying enzymes. In eukaryotic organisms, chromatin organization allows tight packaging of the genomewhile still allowing access to transcriptional machinery. The basic unit of chromatin is the nucleosome, which consists of DNA wrapped around an octamer of histone p...

BACKGROUND Recognition of the airway epithelium as a central mediator in the pathogenesis of asthma has necessitated greater understanding of the aberrant cellular mechanisms of the epithelium in asthma. The architecture of chromatin is integral to the regulation of gene expression and is determined by modifications to the surrounding histones and DNA. The acetylation, methylation, phosphorylat...

Ligninolytic fungi secrete extracellular lignin-modifying enzymes (LME) that degrade plant polymers for fungal nutrition but are, because of their broad substrate specificity, also applicable the degradation many hazardous pollutants. Laccase is one most well characterized LME and involved in removal recalcitrant aromatic compounds with or without assistance laccase-mediators. The fungus Rigido...