bilateral synchronous male breast cancer is very rare. a 63-year-old male presented with rapidly progressive enlarging bilateral breast masses without ulceration and bloody nipple discharge. synchronous bilateral breast cancer was diagnosed by fine needle aspiration cytology. pathology study revealed grade 2 invasive ductal carcinoma in both breasts. he underwent a bilateral modified radical ma...

BACKGROUND Building on earlier work, the toxicity probability interval (TPI) method, we present a modified TPI (mTPI) design that is calibration-free for phase I trials. PURPOSE Our goal is to improve the trial conduct and provide more effective designs while maintaining the simplicity of the original TPI design. METHODS Like the TPI method, the mTPI consists of a practical dose-finding sch...

The purpose of this study is to modify lignin for better blending with general purpose synthetic polymers. The possible advantages by using this modification would be cost reduction, better physical properties, and biodegradability. In this study, butyrolactone-modified lignin (BLL) and tetrahydrofuran-modified lignin (THFL) were used for aliphatic chain modification of lignin using an acid-cat...

An isostructural series of anion radical salts, β'-(EtxMe4−xZ)[Pd(dmit)2]2 (x = 0–2, Z = P, As, Sb), with a quasi-triangular lattice comprising the dimer unit [Pd(dmit)2]2 − belong to a strongly correlated electron system with geometrical frustration. Intra and interdimer transfer integrals between the frontier molecular orbitals, which characterize the strength of electron correlation and degr...

Sliding knots are commonly used in arthroscopic surgery and can be problematic in terms of strength and loop security. A new sliding knot for arthroscopic surgery, a modified racking hitch (MRH) knot, is described. The knot is essentially a modified cow's hitch knot that includes two self-locking loops. By tensioning the loop strands, a snug knot is created without backward sliding and provides...

We present a 61 year old Para 4 woman who presented with stage II Infiltrating lobular carcinoma of the breast after modified radical mastectomy. She was treated with Tamoxifen for seven years. She was diagnosed with multiple myeloma during year seven post mastectomy because of wrist pain. She was treated with melphalan, prednisone and allopurinol which she tolerated well and the pain in the wr...

AIM To evaluate the efficacy of glycopyrrolate oral solution (1 mg/5 mL) in managing problem drooling associated with cerebral palsy and other neurologic conditions. METHOD Thirty-eight patients aged 3-23 years weighing at least 27 lb (12.2 kg) with severe drooling (clothing damp 5-7 days/week) were randomized to glycopyrrolate (n = 20), 0.02-0.1 mg/kg three times a day, or matching placebo (...

Generally digital signature algorithms are based on a single hard problem like prime factorization problem, discrete logarithm problem, elliptic curve problem. If one finds solution of this single hard problem then these digital signature algorithms will no longer be secured and due to large computational power, this may be possible in future. There are many other algorithms which are based on ...

The aim of this study was to evaluate the proliferation and adhesion of mesenchymal cells (3T3/NIH) in Dulbecco's Modified Eagle Medium(DMEM) supplemented with Platelet-Poor Plasma (PPP) in aPlatelet-Rich Fibrin (PRF) scaffold. Human blood was obtained and processed in a centrifuge considering the equation G=1.12xRx(RPM/1000)2 to obtain PRF and PPP.Cell adhesion and maintenance analyses were pe...

BACKGROUND The complex interplay between ethnicity, Fitzpatrick skin type (FST), and hirsutism in patients with polycystic ovarian syndrome (PCOS) is poorly understood. OBJECTIVE In this cross-sectional, retrospective analysis, we examined the prevalence, severity, and distribution of hirsutism with clinician-rated site-specific and total modified Ferriman-Gallwey (mFG) visual scoring in a di...