نتایج جستجو برای: modified biophysical profile
تعداد نتایج: 489490 فیلتر نتایج به سال:
Markov state models (MSMs) have proven to be useful tools in simulating large and slowly-relaxing biological systems like proteins. MSMs model proteins through dynamics on a discrete-state energy landscape, allowing molecules to effectively sample large regions of phase space. In this work, we use aspects of MSMs to ask: is protein folding mechanistically robust? We first provide a definition o...
Protein ubiquitination controls the cellular fate of numerous eukaryotic proteins. Despite its importance, many fundamental questions remain regarding its mechanism. One such question is how ubiquitination alters the biophysical properties of the modified protein and whether these alterations are significant in the cellular context. In this study, we investigate the effects of ubiquitination on...
In this paper, we consider improving maximum likelihood inference for the scale parameter of Lomax distribution. The improvement is based on using modifications to estimator Barndorff-Nielsen modification profile function. We apply these obtain improved estimators distribution in presence a nuisance shape parameter. Due complicated expression Barndorff-Nielsen's modification, several approximat...
This paper investigates the sensitivities of model outputs to model parameter values within a Biophysical Toolbox developed as part of a Decision Support System (DSS) for integrated catchment assessment and management of land and water resources in the highland regions of northern Thailand. The toolbox contains a hydrological module based upon the IHACRES rainfall-runoff model, a crop model (CA...
Histones form the protein core around which genomic DNA is wrapped in eukaryotic chromatin. Numerous genetic studies have established that the structure and transcriptional state of chromatin are closely related to histone post-translational modifications. Further elucidation of the precise mechanistic roles for individual histone modifications requires the ability to isolate and study homogene...
Natural and engineered genetic systems require the coordinated expression of proteins. In bacteria, translational coupling provides a genetically encoded mechanism to control expression level ratios within multi-cistronic operons. We have developed a sequence-to-function biophysical model of translational coupling to predict expression level ratios in natural operons and to design synthetic ope...
The planetary boundaries framework defines a safe operating space for humanity based on the intrinsic biophysical processes that regulate the stability of the Earth system. Here, we revise and update the planetary boundary framework, with a focus on the underpinning biophysical science, based on targeted input from expert research communities and on more general scientific advances over the pas...
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