The dynamic collision behavior of the electro-oxidation of single Ag nanoparticles is observed at Au microelectrodes using stochastic single-nanoparticle collision amperometry. Results show that an Ag nanoparticle collision/oxidation event typically consists of a series of 1 to ∼10 discrete "sub-events" over an ∼20 ms interval. Results also show that the Ag nanoparticles typically undergo only ...

Many small-molecule anti-cancer drugs have short blood half-lives and toxicity issues due to non-specificity. Nanotechnology has shown great promise in addressing these issues. Here, we report the development of an anti-cancer drug gemcitabine-conjugated iron oxide nanoparticle for glioblastoma therapy. A glioblastoma targeting peptide, chlorotoxin, was attached after drug conjugation. The nano...

We study the dynamics of a laser-trapped nanoparticle in high vacuum. Using parametric coupling to an external excitation source, the linewidth of the nanoparticle's oscillation can be reduced by three orders of magnitude. We show that the oscillation of the nanoparticle and the excitation source are synchronized, exhibiting a well-defined phase relationship. Furthermore, the external source ca...

This paper describes the formation of organic nanorods induced by monolayer-protected inorganic nanoparticles. Alkanes and alkane derivatives, such as n-carboxylic acids, self-assemble on highly oriented pyrolytic graphite (HOPG) into a persistent molecular packing structure that is dictated by the epitaxial interaction between the carbon chain plane and the HOPG basal plane. Carboxylic acids f...

The targeted delivery of nanoparticle carriers holds tremendous potential to transform the detection and treatment of diseases. A major attribute of nanoparticles is the ability to form multiple bonds with target cells, which greatly improves the adhesion strength. However, the multivalent binding of nanoparticles is still poorly understood, particularly from a dynamic perspective. In previous ...

OBJECTIVE To evaluate the efficacy of subconjunctival nanoparticle carboplatin in the treatment of transgenic murine retinoblastoma. METHODS Dendrimeric nanoparticles loaded with carboplatin were prepared. Forty LHbeta-Tag mice were randomly assigned into 4 groups and treated at 10 weeks of age. Each mouse received a single subconjunctival injection in one eye, and the opposite eye was left u...

Using classical density functional theory, the structure of a molecular fluid around a cylindrical nanoparticle near a solid substrate is studied. The solvent-mediated force between the nanoparticle and the substrate is calculated in both the nematic and isotropic phases of the solvent. In the nematic phase, the force is short ranged and arises due to interaction between high-density regions ne...

Nanoparticle exposure in pregnancy may result in placental damage and fetotoxicity; however, the factors that determine fetal nanoparticle exposure are unclear. Here we have assessed the effect of gestational age and nanoparticle composition on fetal accumulation of maternally-administered nanomaterials in mice. We determined the placental and fetal uptake of 13 nm gold nanoparticles with diffe...

A new route for tailoring the behavior of colloidal suspensions through nanoparticle additions is reviewed. Specifically, the interparticle interactions, phase behavior, 3-D structure, and rheological properties of microsphere–nanoparticle mixtures that possess both high charge and size asymmetry are described. Negligibly charged microspheres, which flocculate when suspended alone, undergo a re...

Cu2ZnSnS4 nanoparticle with an average diameter of approximately 31 nm has been successfully synthesized by a time effective microwave fabrication method. The crystal structure, surface morphology, and microstructure of the Cu2ZnSnS4 nanoparticle were characterized. Moreover, the visible light photocatalytic ability of the Cu2ZnSnS4 nanoparticle toward degradation of methylene blue (MB) was als...