We consider a re-sampling scheme for estimation of the population parameters in mixed-effects nonlinear regression models type used, example, clinical pharmacokinetics. provide two-stage procedure which resamples (or recycles), via random weightings, various parameter's estimates to construct consistent their respective sampling distributions. In particular, we establish under rather general di...

Generalized F tests were introduced by Michalski and Zmyślony (1996) for variance components and later (1999) for linear functions of parameters in mixed linear models. We now use generalized polar coordinates to obtain, for the second case, tests that are more powerful for selected families of alternatives.