The effects of non-steroidal anti-inflammatory drugs and prostaglandins E(2) and F(2alpha) on the secretory and electrical activity of isolated rabbit fundic mucosa have been studied. Spontaneous acid secretion was inhibited by serosal side application of sodium thiocyanate (6x10(-2)M) and the resulting alkali secretion measured by pH stat tiration. Serosal side application of indomethacin (10(...

Previous work reported from JPL has included characterization of eleetrode kinetics and alkali atom transport from electrodes including MO) W, WRhX, WPtX(Mn), in sodium AMTEC cells and vapor exposure cells; and Mo in potassium vapor exposure cells. [Williams, cl al., 1990a, 1991, 1992] These studies were generally performed in cells with small area electrodes (about 1 to 5 cm2), and device geom...

The properties of the cGMP-dependent channel present in membrane vesicles prepared from intact isolated bovine rod outer segments (ROS) were investigated with the optical probe neutral red. The binding of neutral red is sensitive to transport of cations across vesicular membranes by the effect of the translocated cations on the surface potential at the intravesicular membrane/water interface (S...

AIM To evaluate the therapeutic effect of netrin-4 on the early acute phase of inflammation in the alkali-burned eye. METHODS Eye drops containing netrin-4 or phosphate buffered saline (PBS) were administered to a alkali-burn-induced corneal acute inflammatory model four times daily. The clinical evaluations, including fluorescein staining and inflammatory index, were performed on day 1, 4 an...

Derived from the cyclic secondary amine 2,2,6,6-tetramethylpiperidine [TMP(H)] by removal of its nitrogen-attached hydrogen atom, the TMP anion 1 has had a 40 year career in the business of selective proton abstraction. Possessing attributes of high steric bulk and low nucleophilicity, without any b-hydrogen atoms (the presence of which often disadvantages its diisopropylamido analogue through ...

A procedure is described for the purification of a neutral protease from fermentation broths of Vibrio proteolyticus. The key feature of the purification scheme is the selective, irreversible inactivation of a contaminating exoenzyme, aminopeptidase, by alkali treatment, rather than removal of this enzyme by conventional chromatographic methods. Fermentation broths or concentrates were brought ...

The selectivity of acetylcholine (A-Ch)-activated channels for alkali cations, organic cations, and nonelectrolytes in cultured muscle cells has been studied. To test the effect of size, charge, and hydrogen-binding capacity of permeant molecules on their permeability, we have obtained the selectivity sequences of alkali cations, compared the permeability of pairs of permeant molecules with sim...

We present classical and quantum studies of the scattering dynamics of Rydberg electron wave packets from the electronic core of alkali atoms. In quantum systems an ideal state for studying such effects is an angularly localized wavepacket in which the primary effect of the scattering is to cause precession. The scattering is enhanced by the application of an external dc electric field. We calc...