Flavonoids are claimed to protect against cardiovascular disease, certain forms of cancer and ageing, possibly by preventing initial DNA damage. Therefore, we investigated the protective effects of crude extract, ethyl acetate fraction and flavonoids (quercetin, quercitrin, isoquercitrin and rutin) isolated from the leaves from Scutia buxifolia against chromosome damage induced by H₂O₂ in human...

Trichosanthes dioica Roxb. (Cucurbitaceae), called Potol in Bengali, Palval in Hindi and pointed gourd in English is a dioecious climber grown in Indian subcontinent and all parts of it have been traditionally used for various medicinal purposes. The present study aimed to evaluate the in vitro antimitotic and genotoxic effect of cucurbitacin enriched extract of T. dioica root using Allium cepa...

Pogostemon auricularius is an aromatic herb belonging to the family Lamiaceae. Objectives: In the present study we have utilized the Allium cepa root tip meristem model to evaluate the cytotoxic and antimitotic potential of P. auricularius. Methods: The roots of Allium cepa were exposed to different concentrations of the aqueous leaf extracts (0.01%, 0.05%, 0.1% and 0.5%), for four different ti...

Gastrointestinal neuroendocrine neoplasms (GI-NENs) arise from neuroendocrine cells distributed mainly in the mucosa and submucosa of the gastrointestinal tract. In 2010, the World Health Organization (WHO) classification of NENs of the digestive system was changed, categorizing these tumors as grade 1 neuroendocrine tumor (NET), grade-2NET, neuroendocrine carcinoma (large- or small-cell type),...

In the continuous presence of Colcemid, the mitotic index in cultures of nine human tumor cell lines began to increase immediately upon addition of the drug. For 12 human normal (nontumorigenic) cell lines, the mitotic index did not begin to increase for some 2 to 3 h after the addition of Colcemid. The effect was independent of whether the cells were of fibroblast or epithelial origin and occu...

Objective: Liver regeneration is necessary to restore hepatic mass and functional capacity after partial hepatectomy (PH). Cynara scolymus (CS) a pharmacologically important plant that contains phenolic acids flavonoids, experimental studies have indicated it has antioxidant hepatoprotective effects. The aim of this study was investigate the role CS in liver PH rats. 
 Methods: A total 36 ...

By SVEN-AGE KILLMANN, EUGENE P. CRONKITE, T. M. FLIEDNER, VIcroR P. BOND AND GEORGE BRECHER T HE PURPOSE of this paper is to define the information that is needed in order to use mitotic indices for computation of time parameters of catenated cytologic compartments such as exist in hemopoiesis. The considerations are also applicable to cell renewal systems in general. A list of symbols and defi...

Normal human keratinocytes, propagated as epithelial outgrowths in vitro, were exposed to different concentrations of methotrexate (MTX) for different periods of time. After a 1-hr exposure, DNA synthesis was inhibited in a reversible manner. No change in the mitotic index was observed. After a 6-hr exposure, both DNA synthesis and mitosis were inhibited, again in a reversible fashion. Prolonge...

Gastrointestinal Cancers (GICs) are the most important causes of mortality and morbidity in industrialized world. Sister chromatid exchange (SCE), as an index of chromosomal instability, involves cancer. The aim of this study is to determine whether SCE frequency is a heritable factor for GIC or not. The study groups consisted of 15 gastrointestinal carcinoma patients, 13 patient relatives and ...

Castration of rats transplanted with the androgen-sensitive Dunning R3327-PAP prostatic tumor results initially in a reduction of tumor growth, but after some time, some of the tumors start to grow again. The relapsed, androgen-insensitive PAP tumor shows a dedifferentiated morphology. In the present study, we examined whether this androgen-independent tumor regrowth was due to an increased cel...