Industrial wastewater is of global concern due to its severe effects on the environment. Compared with municipal wastewater, industrial wastewater generally contains the high concentration of toxic or no biodegradable pollutants. In recently year, scientific showed that scallop could filtration wastewater. Therefore, it was decided to determine the mechanistic toxicity of wastewater contained N...

A mitochondrion is a cellular organelle able to produce energy in the form of adenosine triphosphate (ATP). As nucleus, mitochondria contain their own genome: mitochondrial DNA (mtDNA). This genome particularly susceptible mutations that are at basis multitude disorders, especially those affecting heart, central nervous system and muscles. Conventional clinical practice applied diseases very li...

Pioglitazone (PG) is one of thiazolidinediones used for the treatment of type II diabetes mellitus. Some reports of its hepatotoxicity exist, but the mechanism of its hepatotoxicity is not well known. In the present study, the protective effect of some ATP suppliers are investigated against mitochondrial toxicity of PG in isolated rat mitochondria. Mitochondrial viability was investigated by MT...

In this study, we investigated the properties of mitochondria to discriminate fresh from frozen-thawed fish fillets. Mitochondria were isolated gilthead seabream fillets and impact freezing was evaluated by measuring permeability mitochondrial membranes. Freezing led permeabilization inner membranes reduced nicotinamide adenine dinucleotide (NADH). The increase in related shock compared physiol...

Flavonoids are proved to be prominent plant-derived compounds generally found in fruit- and vegetable- rich diets with free radicals quenching ability. Quercetin, a member of flavonoids subclass – flavonols, has gained major attention due its overwhelming potential. Quercetin was demonstrated preserve diverse degenerative diseases by inhibiting lipid peroxidation. In the present paper, we deal ...

Mitochondrial fusion is essential to maintain genomic stability and physiological functions of mitochondria. Since mitochondrial fission work in concert regulate morphology functions, it has been challenging quantitatively measure the direct roles apoptosis cancer progression. Here, we report development a high-throughput vitro method quantify through single mitochondria analysis by laboratory-...

The article provides information on the effect of pesticides - butylcaptax and droppa respiration oxidative phosphorylation liver mitochondria in rat rats their embryos. It has been shown that reduce oxidation succinate α-ketoglutarate V4*, V3 V dnf states drug conjugation pregnant animals most significant inhibition ADF formation respiratory chain fatal maternal occurs via NAD-dependent pathwa...

The majority of proteins localised to mitochondria are encoded by the nuclear genome, with approximately 1500 imported into mammalian mitochondria. Dysfunction in this fundamental cellular process is linked a variety pathologies including neuropathies, cardiovascular disorders, myopathies, neurodegenerative diseases and cancer, demonstrating importance mitochondrial protein import machinery for...

The mitochondrion is often referred as the cellular powerhouse because organelle oxidizes organic acids and NADH derived from nutriments, converting around 40% of Gibbs free energy change these reactions into ATP, major currency cell metabolism. Mitochondria are thus microscopic furnaces that inevitably release heat a by-product reactions, this contributes to body warming, especially in endothe...

Mitochondria, which play a critical role in energy production by oxidative respiration, are highly dynamic organelles and their double membranes undergo frequent events of fusion fission. Mitochondria believed to be derived from the endosymbiosis proteobacteria, thus mitochondria still contain own DNA, mitochondrial DNA (mtDNA). Several copies mtDNA form nucleoid with DNA-binding proteins. Rece...