نتایج جستجو برای: mitf

تعداد نتایج: 1126  

2016
Jianxin Xia Yanlong Wang Fuqiu Li Jinfeng Wang Yan Mu Xianglin Mei Xue Li Wenjing Zhu Xianhua Jin Kai Yu

Malignant melanoma (MM) is a type of malignant tumor, which originates from neural crest melanocytes. MM progresses rapidly and results in a high mortality rate. The present study aims to investigate the expression of microphthalmia transcription factor (MITF), the S100 protein, and HMB-45 in MM and pigmented nevi. A total of 32 MM samples (including three skin metastasis, three lymph node meta...

2012
Dongsheng Yan Xiang Da Dong Xiaoyan Chen Shasha Yao Lihua Wang Jiao Wang Chao Wang Dan-Ning Hu Jia Qu LiLi Tu

MicroRNAs (miRNAs) are endogenous small non-coding RNAs that play central roles in diverse pathological processes. In this study, we investigated the effect of microRNA-182 (miR-182) on the development of posterior uveal melanomas. Initially, we demonstrated that miR-182 expression was dependent on p53 induction in uveal melanoma cells. Interestingly, transient transfection of miR-182 into cult...

2016
Hee-Sun Lim Suna Jin Sook Jung Yun

As a key regulator of melanogenesis, p53 controls microphthalmia-associated transcription factor (MITF) and tyrosinase expression. The anti-oxidant enzyme heme oxygenase-1 (HO-1) is induced by various forms of cellular stress and diverse oxidative stimuli. However, few studies have examined the role of HO-1 in melanogenesis. Therefore, the aim of this study was to determine the role of HO-1 in ...

2013
Jingxing Ou Kapil Bharti Alessandro Nodari Stefano Bertuzzi Heinz Arnheiter

During vertebrate eye development, the transcription factor MITF acts to promote the development of the retinal pigment epithelium (RPE). In embryos with Mitf mutations, the future RPE hyperproliferates and is respecified as retinal tissue but only in a small portion of the dorsal RPE. Using a series of genetic crosses, we show that this spatial restriction of RPE respecification is brought abo...

Journal: :Journal of cell science 2003
Dong-Seok Kim Eui-Soo Hwang Jai-Eun Lee Sook-Young Kim Sun-Bang Kwon Kyoung-Chan Park

Sphingosine-1-phosphate (S1P) has emerged as a bioactive lipid modulator that mediates a variety of cell functions. However, the effects of S1P on melanogenesis are not well known. Therefore, we investigated the actions of S1P on melanin synthesis using a spontaneously immortalized mouse melanocyte cell line, Mel-Ab. This study shows that S1P significantly inhibits melanin synthesis in a concen...

Journal: :BioFactors 2013
K J Senthil Kumar M Gokila Vani Sheng-Yang Wang Jiunn-Wang Liao Li-Sung Hsu Hsin-Ling Yang You-Cheng Hseu

Gallic acid (GA) is a phenolic compound, which has been reported to suppress melanogenesis in melanoma cells. However, the molecular mechanism underlying this inhibitory effect was poorly understood. In this article, we revealed that GA down-regulated melanogenic regulatory genes including tyrosinase, tyrosinase related protein-1 (TRP-1), and dopachrome tatamerase (Dct) expression at transcript...

Journal: :Molecular medicine reports 2016
Yong Chen Fuwei Yang Hexin Zheng Jianda Zhou Ganghua Zhu Peng Hu Weijing Wu

The present study aimed to investigate the molecular pathology of Waardenburg syndrome type II in three families, in order to provide genetic diagnosis and hereditary counseling for family members. Relevant clinical examinations were conducted on the probands of the three pedigrees. Peripheral blood samples of the probands and related family members were collected and genomic DNA was extracted....

2017
J. Zhang Y. Liu Z. Zhu S. Yang K. Ji S. Hu X. Liu J. Yao R. Fan C. Dong

It has been demonstrated that microRNAs (miRNAs) play important roles in the control of melanogenesis and hair color in mammals. By comparing miRNA expression profiles between brown and white alpaca skin, we previously identified miR508-3p as a differentially expressed miRNA suggesting its potential role in melanogenesis and hair color formation. The present study was conducted to determine the...

Journal: :Head & neck 2008
Luc G Morris Yong Hannah Wen Daisuke Nonaka Mark D DeLacure David I Kutler Youming Huan Beverly Y Wang

BACKGROUND Histologic diagnosis of mucosal melanoma of the head and neck is difficult, requiring immunohistochemical stains which are less reliable than in cutaneous lesions. PNL-2 is a novel marker that has not been examined in mucosal melanoma. METHODS Nine formalin-fixed tissue sections of mucosal melanoma were stained with PNL-2, human melanoma black (HMB)-45, Melan-A, S-100, and micropht...

2017
Li Lu Li Rao Huanhuan Jia Jun Chen Xingyan Lu Guozhu Yang Qingnan Li Kenneth Ka Ho Lee Li Yang

Activation of osteoblasts in bone formation and osteoclasts in bone resorption is important during the bone fracture healing process. There has been a long interest in identifying and developing a natural therapy for bone fracture healing. In this study, we investigated the regulation of osteoclast differentiation by baicalin, which is a natural molecule extracted from Eucommiaulmoides (small t...

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