Various methods of induction of labour may be associated with risk and complications. Therefore, this study has been undertaken to compare the safety and efficacy of intra-vaginal misoprostol (PGE1 analogue) with intra-cervical dinoprostone (PGE2) in progress and induction of labour, the maternal side effects and the foetal outcome. 40 pregnant women aged between 16-35 years with indication of ...

BACKGROUND From 2001 to March 2006, Planned Parenthood Federation of America (Planned Parenthood) health centers throughout the United States provided medical abortions principally by a regimen of oral mifepristone, followed 24-48 h later by vaginal misoprostol. In late March 2006, analyses of serious uterine infections following medical abortions led Planned Parenthood to change the route of m...

BACKGROUND Postpartum haemorrhage (PPH) is a leading cause of maternal death in Sokoto State, Nigeria, where 95% of women give birth outside of a health facility. Although pilot schemes have demonstrated the value of community-based distribution of misoprostol for the prevention of PPH, none have provided practical insight on taking such programs to scale. METHODS A community-based system for...

BACKGROUND Using misoprostol to prevent postpartum haemorrhage (PPH) in home-birth settings remains controversial. OBJECTIVES To review the safety and effectiveness of oral misoprostol in preventing PPH in home-birth settings. SEARCH STRATEGY The Cochrane Library, PubMed, and POPLINE were searched for articles published until 31 March 2012. SELECTION CRITERIA Studies, conducted in low-res...

OBJECTIVES To analyze and determine the safety and effectiveness of induced fetal demise as an adjunctive method in outpatient abortion for patients with advanced pregnancies and to evaluate the independent effect of intrauterine misoprostol administered after amniotomy in late abortion. METHODS During a 9-year period, 1677 abortions were performed for patients whose pregnancies ranged from 1...

OBJECTIVE To compare the efficacy of the vaginal and sublingual administration of the synthetic prostaglandin misoprostol with the currently used oral administration route in second-trimester medical abortion. METHODS This was a prospective randomized trial of medical abortion with misoprostol after mifepristone priming at 14-24 weeks of gestation. From 2009 to 2013, recruited women received ...

The current gold standard for treating postpartum hemorrhage (PPH) due to atony is intravenous (IV) oxytocin1. However, access to this specific drug and the capacity for its timely intravenous administration are lacking in settings with limited resources, especially at lower levels of the health care system. Misoprostol, a tablet that requires no additional supplies and/or specialized skills to...

BACKGROUND Mifepristone, followed 48 hours later by administration of misoprostol, is a well-established regimen for medical termination of pregnancy (TOP). Although this regimen is effective, its inflexibility may limit its provision in an outpatient service. OBJECTIVE To confirm that misoprostol administration is effective whether administered 24, 48 or 72 hours after oral mifepristone. D...

Misoprostol, a prostaglandin E1 analogue, is first used to prevent peptic ulcers. The FDA-approved indication in the product labelling for prevention and treatment of intestinal ulcer disease caused by use nonsteroidal anti-inflammatory medications. main advantages misoprostol include it's reasonably priced, compared other prostaglandins, it has modest effects on smooth muscle heart bronchial t...

Background: Misoprostol use in early pregnancy failure is varied and dose not well established. Aim of this study was to compare efficacy side effects 600 versus 800 micrograms vaginal misoprostol failure.Methods: A randomized prospective observational conducted the postgraduate department obstetrics gynaecology, SMGS hospital Jammu from November 2018 October 2019 after getting approval ethical...