MicroRNA-offset-RNAs (moRNAs) were recently detected as highly abundant class of small RNAs in a basal chordate. Using short read sequencing data, we show here that moRNAs are also produced from human microRNA precursors, albeit at quite low expression levels. The expression levels of moRNAs are unrelated to those of the associated microRNAs. Surprisingly, microRNA precursors that also show moR...

BACKGROUND MicroRNA are a class of small RNAs that regulate gene expression by inhibiting translation of protein encoding transcripts through targeting of a microRNA-protein complex by base-pairing of the microRNA sequence to cognate recognition sequences in the 3' untranslated region (UTR) of the mRNA. Target identification for a given microRNA sequence is generally accomplished by informatics...

Chronic low-level inflammation during the aging process is a key risk factor for activation of resident cells brain innate immune system (microglia and astrocytes). Such leads to development neuroinflammation cognitive impairment which are typical neurodegenerative diseases such as Alzheimers disease, vascular dementia, Parkinson disease etc. Currently, there lack minimally invasive, affordable...

Background: MicroRNA-99a has been believed to play a critical role in progression in various cancers; however, the prognostic and clinicopathological value of microRNA-99a in cancers remains unclarified. Methods and Results: We first evaluated the prognostic significance of microRNA-99a expression in 21 human cancer types in The Cancer Genome Atlas (TCGA). Patients with lower microRNA-99a level...

BACKGROUND Early life stress has been demonstrated to increase the risk of developing depression in adulthood. However, the roles and associated molecular mechanisms of stresses in the onset and relapse of depression have yet to be fully elucidated. METHODS Depression-like behaviors were induced in rats by maternal deprivation and chronic unpredictable stress. Depression- and anxiety-like beh...

micrornas constitute a group of small non-coding rnas that negatively regulate gene expression. aside from their contribution to biological and pathological pathways, altered expression of micrornas is reported in bio-fluid samples, such as serum. to employ serum's micrornas as potential biomarkers, it is crucial to develop an efficient method for microrna quantification, avoiding pre-analytica...

BACKGROUND MicroRNAs are regulators of gene expression, which act mainly by decreasing mRNA levels of their multiple targets. Deregulated microRNA expression has been shown for acute myeloid leukemia, a disease also characterized by altered gene expression associated with distinct genomic aberrations such as nucleophosmin (NPM1) mutations. To shed further light on the role of deregulated microR...