نتایج جستجو برای: mir 499
تعداد نتایج: 47909 فیلتر نتایج به سال:
Diabetes is a progressive metabolic disorder that can ultimately lead to serious chronic vascular complications including renal failure, vision loss, and cardiac dysfunction (Ruiz and Chakrabarti, 2013). Diabetic cardiomyopathy is responsible for higher incidence of sudden cardiac death and represents the leading cause of morbidity and mortality among the diabetic patients (Aksnes et al., 2007;...
BACKGROUND Recently, elevation of circulating muscle-specific microRNA (miRNA) levels has been reported in patients with acute myocardial infarction. However, it is still unclear from which part of the myocardium or under what conditions miRNAs are released into circulating blood. The purpose of this study was to identify the source of elevated levels of circulating miRNAs and their function in...
BACKGROUND A characteristic of both clinical and experimental atrial fibrillation (AF) is atrial electric remodeling associated with profound reduction of L-type Ca(2+) current and shortening of the action potential duration. The possibility that microRNAs (miRNAs) may be involved in this process has not been tested. Accordingly, we assessed the potential role of miRNAs in regulating experiment...
We aimed to investigate the correlation between the four common single nucleotide polymorphisms (SNPs) in microRNAs (miR146a rs2910164, miR-196a2 rs11614913, miR-499 rs3746444 and miR-149 rs2292832) and hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) risk through a systematic review and meta-analysis. Odds ratios (ORs) along with 95% confidence intervals (95% CIs) were pool...
RATIONALE Direct reprogramming of cardiac fibroblasts to cardiomyocytes has recently emerged as a novel and promising approach to regenerate the injured myocardium. We have previously demonstrated the feasibility of this approach in vitro and in vivo using a combination of 4 microRNAs (miR-1, miR-133, miR-208, and miR-499) that we named miR combo. However, the mechanism of miR combo mediated di...
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