Peroxisome proliferator-activated receptor c (PPARc) is a key transcription factor in mammalian adipogenesis. Genome-wide approaches have identified thousands of PPARc binding sites in mouse adipocytes and PPARc upregulates hundreds of protein-coding genes during adipogenesis. However, no microRNA (miRNA) genes have been identified as primary PPARc-targets. By integration of four separate datas...

Though music is fundamentally an aural phenomenon, we often communicate about music through visual means. The paper examines a number of visualization techniques developed for music, focusing especially on those developed for music analysis by specialists in the field, but also looking at some less successful approaches. It is hoped that, by presenting them in this way, those in the MIR communi...

MicroRNAs (miRNAs) are small, conserved RNAs known to regulate several biological processes by influencing gene expression in eukaryotes. The implication of miRNAs as another player of regulatory layers during heart development and diseases has recently been explored. However, there is no study which elucidates the profiling of miRNAs during development of heart till date. Very limited miRNAs h...

Human forkhead box P3 (FOXP3)+ cluster of differentiation (CD)25+CD4+ regulatory T cells (Tregs) are a type of T cell that express CD4, CD25 and FOXP3, which are critical for maintaining immune homeostasis. The present study aimed to determine the mechanisms underlying Treg function. The GSE11292 dataset was downloaded from the Gene Expression Omnibus, which included data from Treg cells at 19 ...

BACKGROUND Skeletal muscle weakness in chronic obstructive pulmonary disease (COPD) carries a poor prognosis, therefore a non-invasive marker of this process could be useful. Reduced expression of muscle-specific microRNA (myomiRs) in quadriceps muscle in patients with COPD is associated with skeletal muscle weakness and changes in muscle fibre composition. Circulating exosomal miRNAs can be me...