Aim: comparative analysis of the expression profile plasma microRNAs and target genes in patients with complicated pregnancy. Materials Methods. A prospective observational study parallel groups was carried out. The included 73 women divided into three groups: main group – 42 preeclampsia (PE), comparison 12 pregnant fetal growth retardation (FGR), control 19 clinically healthy uncomplicated An...

Differentiating glioma from primary central nervous system lymphoma (PCNSL) can be challenging, and current diagnostic measures such as MRI biopsy are of limited efficacy. Liquid biopsies, which detect circulating biomarkers microRNAs (miRs), may provide valuable insights into for improved discrimination. This review aimed to investigate the role specific miRs in diagnosing differentiating PCNS...

In the recent years deregulation for microRNAs expression pattern have emerged as a possible molecular factor for carcinogenesis. It has been reported that the expression of miR-9 was down-regulated in human gastric adenocarcinoma. To figure out the molecular mechanism of this down regulation, the methylation status in promoters of miR-9 family loci were compared in the human gastric adenocarci...

Epilepsy is the third most common chronic brain disorder which is characterized by an enduring predisposition to generate seizures. Mesial Temporal Lobe Epilepsy (MTLE) is the most common type of refractory epilepsy. Increasing evidence indicates that neuroinflammation plays a critical role in the pathogenesis of MTLE. Hundreds of micro-RNAs have been found to be abnormally expressed in epilept...

MicroRNA-147 (miR-147) had been previously found induced in synoviocytes by inflammatory stimuli derived from T cells experimental arthritis. This study was designed to verify whether loss of its function might alleviate events joints and rheumatoid arthritis (RA). Dark Agouti (DA) rats were injected intradermally with pristane induce arthritis, rno-miR-147 antagomir locally administrated into ...

Abstract Background Emerging evidence suggests that epithelial cell-derived microRNAs (miRNA) are involved in the pathogenesis of inflammatory bowel disease; however, as now specific implications real clinical practice, especially relation to biologics use yet far-fetched. Therefore, we tried investigate cell derived miRNA signatures related and endoscopic activity Crohn’s disease (CD) patients...