An emerging concept in transcriptional regulation is that a class of truncated transcription factors (TFs), called microProteins (miPs), engages in protein-protein interactions with TF complexes and provides feedback controls. A handful of miP examples have been described in the literature but the extent of their prevalence is unclear. Here we present an algorithm that predicts miPs and their t...

Domain-specific model integrated program synthesis (MIPS) environments are created according to a modeling paradigm – a description of the class of models that can be created using the system. Just as model integrated computing applications are executable instances of domain models, domain models can be viewed as instances of meta-models. Desired modeling environment characteristics are selecte...

The self-renewal and differentiation properties of cancer stem cells (CSCs) are regulated and maintained by the CSC niche. However, the mechanism of this maintenance, especially the maintenance contributed by differentiated cancer cells, remains to be fully elucidated. Recently, we have established a model of CSCs, miPS-LLCcm, from mouse induced pluripotent stem cells (miPSCs). In vitro culture...

Herein, we report on molecularly imprinted polymers (MIPs) for detecting formaldehyde vapors in air streams. A copolymer thin film consisting of styrene, methacrylic acid, and ethylene glycol dimethacrylate on quartz crystal microbalance (QCM) yielded a detection limit of 500 ppb formaldehyde in dry air. Surprisingly, these MIPs showed specific behavior when tested against a range of volatile o...

This paper develops a new generalized-branching technique called “explicitconstraint branching” (ECB) to improve the performance of branch-andbound algorithms for solving mixed-integer programs (MIPs). ECB adds structure to a MIP, in the form of auxiliary constraints and auxiliary integer variables, to allow branching on groups of (original) integer variables that would not otherwise be possibl...

In this assignment, you will become familiar with the MIPS integer and floating point pipelines. You will create a cycle-accurate simulator of an in-order MIPS processor, called mipsim, that supports 32-bit integer and floating point operations. Your simulator will be very basic: it will model all the necessary pipeline interlocks to enforce correct pipeline execution, but it will not support o...

In this study, we investigate molecularly imprinted polymers (MIPs), which form a three-dimensional image of the region at and around the active binding sites of pharmaceutically active insulin or are analogous to b cells bound to insulin. This approach was employed to create a welldefined structure within the nanospace cavities that make up functional monomers by cross-linking. The obtained MI...

The aim of this work was to investigate the possibility of employing Molecularly Imprinted Polymers (MIPs) as a controlled release device for 5-fluorouracil (5-FU) in biological fluids, especially gastrointestinal ones, compared to Non Imprinted Polymers (NIPs). MIPs were synthesized using methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as crosslinking ag...

Molecularly imprinted polymers are synthetic polymers possessing specific cavities designed for target molecules. They are prepared by copolymerization of a cross-linking agent with the complex formed from a template and monomers that have functional groups specifically interacting with the template through covalent or noncovalent bonds. Subsequent removal of the imprint template leaves specifi...