The possibility that bradykinin, a potent vasodilator, might be a physiological antagonist of the renin-angiotensin system was investigated. 11 norman subjects, ranging in age from 21 to 33 yr were studied. Seven of the subjects were given a 10 meq sodium, 100 meq potassium, 2500 ml isocaloric diet. After metabolic balance was achieved, they were infused with either 1 liter of 5 per cent glucos...

The disk dimension of a planar graph G is the least number k for which G embeds in the plane minus k open disks, with every vertex on the boundary of some disk. Useful properties of graphs with a given disk dimension are derived, leading to an efficient algorithm to obtain an outerplanar subgraph of a graph of disk dimension k by removing at most 2k−2 vertices. This reduction is used to obtain ...

Let M n M^n be a smooth compact manifold with boundary. We show that for generic ...

Let K be a complete and algebraically closed valued field of characteristic 0. We prove that the set of rational integers is positive existentially definable in the field M of meromorphic functions on K in the language Lz of rings augmented by a constant symbol for the independent variable z and by a symbol for the unary relation “the function x takes the value 0 at 0”. Consequently, we prove t...

Let K be a simplicial complex and suppose that K collapses onto L. Define n to be 1 minus the minimum number of collapsible sets it takes to cover L. Then the discrete Lusternik–Schnirelmann category of K is the smallest n taken over all such L. In this paper, we give an algorithm which yields an upper bound for the discrete category. We show our algorithm is correct and give several bounds for...

Let K be a complete and algebraically closed valued field of characteristic 0. We prove that the set of rational integers is positive existentially definable in the field M of meromorphic functions on K in the language L z of rings augmented by a constant symbol for the independent variable z and by a symbol for the unary relation ‘‘the function x takes the value 0 at 0’’. Consequently, we prov...

To build the spindle at mitosis, motors exert spatially regulated forces on microtubules. We know that dynein pulls on mammalian spindle microtubule minus-ends, and this localized activity at ends is predicted to allow dynein to cluster microtubules into poles. How dynein becomes enriched at minus-ends is not known. Here, we use quantitative imaging and laser ablation to show that NuMA targets ...