Glutathione S-transferases in the small intestine function in detoxification of electrophilic compounds ingested in foods, dietary supplements, and orally administered drug preparations. Although the required substrate glutathione (GSH) is synthesized in the intestinal enterocytes, the rate of synthesis is slow compared to both the maximal GST activity and the rate of uptake of luminal GSH. GSH...

Glutathione (GSH) plays a critical role in many cellular processes, including the metabolism and detoxification of oxidants, metals, and other reactive electrophilic compounds of both endogenous and exogenous origin. Because the liver is a major site of GSH and glutathione S-conjugate biosynthesis and export, significant effort has been devoted to characterizing liver cell sinusoidal and canali...

Neuronal degeneration in multiple sclerosis has been linked to oxidative stress. Dimethyl fumarate (DMF) is an effective oral therapeutic option shown to reduce disease activity and progression in patients with relapsing-remitting multiple sclerosis. DMF activates the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) leading to increased synthesis of the major cellular ant...

The present review aims at highlighting recent advances in the development of photocatalysts devoted to cancer therapy applications. We pay especial attention engineering aspects different nanomaterials including inorganic semiconductors, organic-based nanostructures, noble metal-based systems or synergistic hybrid heterostructures. Furthermore, we also explore and correlate structural optical ...

Enteric glia play an important neuroprotective role in the enteric nervous system (ENS) by producing neuroprotective compounds such as the antioxidant reduced glutathione (GSH). The specific cellular pathways that regulate glial production of GSH and how these pathways are altered during, or contribute to, neuroinflammation in situ and in vivo are not fully understood. We investigated this issu...

The ascorbate (AsA)–glutathione (GSH) metabolism pathway is an important antioxidant system in cadmium (Cd) detoxification; the AsA–GSHpathway generally regulated by a specific set of functional genes. However, transcription factors involved AsA–GSH have yet to be identified. Herein, we transformed heat shock factor SpHsfA4c from Sedum plumbizincicola into Populus. × canescens. Under 100 μM CdC...

Glutathione is an antioxidant that plays a role in preventing free radicals and reducing oxidative stress, including patients with type 2 diabetes mellitus (DMT2). One of the factors affect glutathione status individual's ability to produce diabetic patients, T-glutathione levels have decreased. This study aims determine effect fruit vegetable consumption habits on plasma T-Glutathione. researc...

Given the increasing importance of boron (B) toxicity, present study investigates roles glutathione (20 mM, GSH) and proline mM) in improvement wheat (Triticum aestivum cv. Altındane) resistance to B toxicity (10 mM B). The plants were raised hydroponic culture with control, B+glutathione, B+proline, proline. B+glutathione B+proline resisted detrimental influences on root shoot lengths, total c...

Background: Goats in India are endangered by various disease outbreaks. A limited number of conditions goats have been investigated with regard to the effect oxidative stress. Oxidative stress is an active field research implicated numerous processes including sepsis, enteritis, pneumonia, mastitis, joint diseases etc. The present work was undertaken study contributing pathological changes natu...

In patients with chronic obstructive pulmonary disease (COPD), an imbalance between oxidants and antioxidants is acknowledged to result in disease development and progression. Cigarette smoke (CS) is known to deplete total glutathione (GSH + GSSG) in the airways. We hypothesized that components in the gaseous phase of CS may irreversibly react with GSH to form GSH derivatives that cannot be red...