BACKGROUND Retinoids (RC), alpha-hydroxy acids (AHA), and salicylic acid (BHA) treat acne through differing mechanisms of action. It is theorized that optimal improvement can be achieved by combining the RC-induced normalization of cellular differentiation, AHA-induced exfoliation in hydrophilic areas, and BHA-induced exfoliation in lipophilic areas. AHA and RC have been combined in a bioengine...

The skin is the largest organ in human body which affected by many diseases. Acne vulgaris (AV) a multifactorial inflammatory disorder affecting areas, and patients constitute large proportion of dermatology clinics worldwide. most severe occurrence during adolescence, self-extension disease with psychological side physical effects. This study aimed to prepare pharmaceutical dosage form (Dermic...

INTRODUCTION A solubilized 5% BPO gel has been developed to enhance the bioavailability, follicular penetration, and efficacy of BPO. METHODS Sixty-five patients with moderate facial acne vulgaris were randomly assigned to apply solubilized 5% BPO gel to one facial side and 5% BPO/1% clindamycin to the contralateral side, twice daily for four or 12 weeks. RESULTS The solubilized BPO gel res...

Acne Vulgaris is a chronic inflammatory disease with multifactorial etiology. It one of the leading reasons for visiting dermatologist. patients undergo considerable amount psychological impairment as face socially and psychologically most important body region. There no sufficient data available on Impact acne QoL in Indian patients. To Determine Quality Life using two different scoring system...

Introduction . Post-acne post-inflammatory hyperpigmentation most often develops in patients with moderate to severe acne. pigmentation can be persistent and last from months several years, which has a negative impact on the patients’ quality of life. It occurs at any age same frequency men women. Aim To evaluate effect dermatocosmetic products – triple serum (containing thiamidol, salicylic ac...

The occurrence of acne in women with hyperandrogenemia is well known; a question remains, however, as to whether a further positive relationship can be detected between the intensity of acne and the levels of testosterone, androgen precursors and sex hormone binding globulin (SHBG). A procedure of interactive data analysis extracting relevant information from original data was applied. Explorat...

Background: Topical retinoid based combinations are recommended to enhance the outcome of acne treatment. Adapalene-benzoyl peroxide (BPO) combination gel was approved in 2009 for acne treatment. The aim of this study was to evaluate the efficacy and tolerability of adapalene 0.1%-benzoyl peroxide 2.5% combination gel compared to adapalene 0.1% gel monotherapy and benzoyl peroxide 2.5% gel mono...

A 41-year-old white man with a long history of acne rosacea was referred for evaluation of a persistent erythematous lesion on his nose. The lesion had been present for 2 years and had proved resistant to topical and oral antibiotic therapy. Examination of the patient’s face revealed malar erythema, scattered acnei form papules , and an absence of comedones, consistent with mild acne rosacea. O...

A cross-sectional, community-based study was performed to determine the prevalence and severity of acne vulgaris in adolescents and of factors influencing the acne severity risk. The presence of acne was clinically determined and the secondary outcome measures of family acne history and the relation of acne to nutrition habits, emotional stress, menstruation, and smoking were recorded in a ques...