Thyroid hormone is a major regulator of thermogenesis, acting both in peripheral organs and on central autonomic pathways. Mice heterozygous for a point mutation in thyroid hormone receptor α1 display increased thermogenesis as a consequence of high sympathetic brown fat stimulation. Surprisingly, despite the hypermetabolism, their body temperature is not elevated. Here we show, using isolated ...

The article by Kouakam et al. in issue 22/17 is a prospective observational study of syncope recurrence in 101 children (mean age 12·6 3; range 7–18 years) undergoing head-up tilt testing for investigation of recurrent unexplained syncope or presyncope. Data are presented for patients recruited between 1990 and 1998, and followed-up for an average of 4 years. Head-up tilt was initially positive...

BACKGROUND Recommended treatment for type 1 hepatorenal syndrome consists of albumin and vasoconstrictor. The optimal albumin dose remains poorly characterized. This meta-analysis aimed to determine the impact of albumin dose on treatment outcomes. METHODS Clinical studies of type 1 hepatorenal syndrome treatment with albumin and vasoconstrictor were sought. Search terms included: hepatorenal...

Background and Aim: Acute kidney injury (AKI) in patients with cirrhosis results high short-term mortality. HRS accounts for approximately 25% of cases prerenal AKI. Recurrence HRS-AKI after treatment is variable, ranging from 25-50% different studies. There limited literature on the factors that predict recurrence HRS-AKI. The aim to assess incidence predicting liver cirrhosis. Also, evaluate ...

Patients with deterioration of the autonomic nervous system can have unexpected or even paradoxical reactions to common cardiovascular drugs. For example, patients with severe neuropathy of the peripheral autonomic system can have a pressor response to phenylephrine eye drops and a paradoxical increase in blood pressure (BP) from the antihypertensive clonidine.1 Currently, the only approved the...