background: cd4+ and cd8+ t cells are the main types of lymphocytes in cell-mediated immunity and play a central role in the induction of efficient immune responses against tumors. the frequencies of t cell subtypes in the peripheral blood and tumor tissues, and draining lymph nodes (dln) can be considered as useful markers for evaluation of the immune system in cancers. methods: in this study,...

The middle levels problem is to find a Hamilton cycle in the middle levels, M2k+1, of the Hasse diagram of B2k+1 (the partially ordered set of subsets of a 2k + 1element set ordered by inclusion). Previously, the best known, from [1], was that M2k+1 is Hamiltonian for all positive k through k = 15. In this note we announce that M33 and M35 have Hamilton cycles. The result was achieved by an alg...

The middle levels conjecture asserts that there is a Hamiltonian cycle in the middle two levels of 2k + 1-dimensional hypercube. The conjecture is known to be true for k ≤ 17 [I. Shields, B.J. Shields and C.D. Savage, Disc. Math., 309, 5271–5277 (2009)]. In this note, we verify that the conjecture is also true for k = 18 by constructing a Hamiltonian cycle in the middle two levels of 37-dimensi...

In this paper we report the development of a micro screw pump for discharging effusion from middle ear for treatment of otitis media. This tool extrudes effusion using a newly designed screw, which rotates at 90,000 rpm in a pipe penetrated through tympanic membrane. This tool satisfies the discharge performance especially for high viscosity effusion while it has smaller diameter such as about ...

Objective: Oxidative stress plays an important role in the onset and progression of diabetic nephropathy. So antioxidant agents may be one of the key treatment strategies for prevention of diabetic nephropathy progression .The aim of this study was to determine the effect of selenium (Se) on micro-albuminuria in type 2 diabetic (T2DM) patients. Materials and Methods: This study was a clinical ...

BACKGROUND Increasing cycling for transport can contribute to improve public health among adults. Micro-environmental factors (i.e. small-scaled street-setting features) may play an important role in affecting the street's appeal to cycle for transport. Understanding about the interplay between individuals and their physical environment is important to establish tailored environmental intervent...